A Deterministic Model Predicts the Properties of Stochastic Calcium Oscillations in Airway Smooth Muscle Cells

Pengxing Cao, Xiahui Tan, Graham Donovan, Michael J Sanderson and James Sneyd

PLOS Computational Biology, 2014, vol. 10, issue 8, 1-15

Abstract: The inositol trisphosphate receptor () is one of the most important cellular components responsible for oscillations in the cytoplasmic calcium concentration. Over the past decade, two major questions about the have arisen. Firstly, how best should the be modeled? In other words, what fundamental properties of the allow it to perform its function, and what are their quantitative properties? Secondly, although calcium oscillations are caused by the stochastic opening and closing of small numbers of , is it possible for a deterministic model to be a reliable predictor of calcium behavior? Here, we answer these two questions, using airway smooth muscle cells (ASMC) as a specific example. Firstly, we show that periodic calcium waves in ASMC, as well as the statistics of calcium puffs in other cell types, can be quantitatively reproduced by a two-state model of the , and thus the behavior of the is essentially determined by its modal structure. The structure within each mode is irrelevant for function. Secondly, we show that, although calcium waves in ASMC are generated by a stochastic mechanism, stochasticity is not essential for a qualitative prediction of how oscillation frequency depends on model parameters, and thus deterministic models demonstrate the same level of predictive capability as do stochastic models. We conclude that, firstly, calcium dynamics can be accurately modeled using simplified models, and, secondly, to obtain qualitative predictions of how oscillation frequency depends on parameters it is sufficient to use a deterministic model.Author Summary: The inositol trisphosphate receptor () is one of the most important cellular components responsible for calcium oscillations. Over the past decade, two major questions about the have arisen. Firstly, what fundamental properties of the allow it to perform its function? Secondly, although calcium oscillations are caused by the stochastic properties of small numbers of is it possible for a deterministic model to be a reliable predictor of calcium dynamics? Using airway smooth muscle cells as an example, we show that calcium dynamics can be accurately modeled using simplified models, and, secondly, that deterministic models are qualitatively accurate predictors of calcium dynamics. These results are important for the study of calcium dynamics in many cell types.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pcbi00:1003783

DOI: 10.1371/journal.pcbi.1003783

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