 Bayesian Inference of Sampled Ancestor Trees for Epidemiology and Fossil CalibrationAlexandra Gavryushkina, David Welch, Tanja Stadler and Alexei J Drummond PLOS Computational Biology, 2014, vol. 10, issue 12, 1-15 Abstract: Phylogenetic analyses which include fossils or molecular sequences that are sampled through time require models that allow one sample to be a direct ancestor of another sample. As previously available phylogenetic inference tools assume that all samples are tips, they do not allow for this possibility. We have developed and implemented a Bayesian Markov Chain Monte Carlo (MCMC) algorithm to infer what we call sampled ancestor trees, that is, trees in which sampled individuals can be direct ancestors of other sampled individuals. We use a family of birth-death models where individuals may remain in the tree process after sampling, in particular we extend the birth-death skyline model [Stadler et al., 2013] to sampled ancestor trees. This method allows the detection of sampled ancestors as well as estimation of the probability that an individual will be removed from the process when it is sampled. We show that even if sampled ancestors are not of specific interest in an analysis, failing to account for them leads to significant bias in parameter estimates. We also show that sampled ancestor birth-death models where every sample comes from a different time point are non-identifiable and thus require one parameter to be known in order to infer other parameters. We apply our phylogenetic inference accounting for sampled ancestors to epidemiological data, where the possibility of sampled ancestors enables us to identify individuals that infected other individuals after being sampled and to infer fundamental epidemiological parameters. We also apply the method to infer divergence times and diversification rates when fossils are included along with extant species samples, so that fossilisation events are modelled as a part of the tree branching process. Such modelling has many advantages as argued in the literature. The sampler is available as an open-source BEAST2 package (https://github.com/CompEvol/sampled-ancestors).Author Summary: A central goal of phylogenetic analysis is to estimate evolutionary relationships and the dynamical parameters underlying the evolutionary branching process (e.g. macroevolutionary or epidemiological parameters) from molecular data. The statistical methods used in these analyses require that the underlying tree branching process is specified. Standard models for the branching process which were originally designed to describe the evolutionary past of present day species do not allow one sampled taxon to be the ancestor of another. However the probability of sampling a direct ancestor is not negligible for many types of data. For example, when fossil and living species are analysed together to infer species divergence times, fossil species may or may not be direct ancestors of living species. In epidemiology, a sampled individual (a host from which a pathogen sequence was obtained) can infect other individuals after sampling, which then go on to be sampled themselves. The models that account for direct ancestors produce phylogenetic trees with a different structure from classic phylogenetic trees and so using these models in inference requires new computational methods. Here we developed a method for phylogenetic analysis that accounts for the possibility of direct ancestors. Date: 2014 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:plo:pcbi00:1003919 DOI: 10.1371/journal.pcbi.1003919 Access Statistics for this article More articles in PLOS Computational Biology from Public Library of Science |
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