Noise Expands the Response Range of the Bacillus subtilis Competence Circuit

Andrew Mugler, Mark Kittisopikul, Luke Hayden, Jintao Liu, Chris H Wiggins, Gürol M Süel and Aleksandra M Walczak

PLOS Computational Biology, 2016, vol. 12, issue 3, 1-21

Abstract: Gene regulatory circuits must contend with intrinsic noise that arises due to finite numbers of proteins. While some circuits act to reduce this noise, others appear to exploit it. A striking example is the competence circuit in Bacillus subtilis, which exhibits much larger noise in the duration of its competence events than a synthetically constructed analog that performs the same function. Here, using stochastic modeling and fluorescence microscopy, we show that this larger noise allows cells to exit terminal phenotypic states, which expands the range of stress levels to which cells are responsive and leads to phenotypic heterogeneity at the population level. This is an important example of how noise confers a functional benefit in a genetic decision-making circuit.Author Summary: Fluctuations, or “noise”, in the response of a system is usually thought to be harmful. However, it is becoming increasingly clear that in single-celled organisms, noise can sometimes help cells survive. This is because noise can enhance the diversity of responses within a cell population. In this study, we identify a novel benefit of noise in the competence response of a population of Bacillus subtilis bacteria, where competence is the ability of bacteria to take in DNA from their environment when under stress. We use computational modeling and experiments to show that noise increases the range of stress levels for which these bacteria exhibit a highly dynamic response, meaning that they are neither unresponsive, nor permanently in the competent state. Since a dynamic response is thought to be optimal for survival, this study suggests that noise is exploited to increase the fitness of the bacterial population.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pcbi00:1004793

DOI: 10.1371/journal.pcbi.1004793

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