Fast and near-optimal monitoring for healthcare acquired infection outbreaks

Bijaya Adhikari, Bryan Lewis, Anil Vullikanti, José Mauricio Jiménez and B Aditya Prakash

PLOS Computational Biology, 2019, vol. 15, issue 9, 1-22

Abstract: According to the Centers for Disease Control and Prevention (CDC), one in twenty five hospital patients are infected with at least one healthcare acquired infection (HAI) on any given day. Early detection of possible HAI outbreaks help practitioners implement countermeasures before the infection spreads extensively. Here, we develop an efficient data and model driven method to detect outbreaks with high accuracy. We leverage mechanistic modeling of C. difficile infection, a major HAI disease, to simulate its spread in a hospital wing and design efficient near-optimal algorithms to select people and locations to monitor using an optimization formulation. Results show that our strategy detects up to 95% of “future” C. difficile outbreaks. We design our method by incorporating specific hospital practices (like swabbing for infections) as well. As a result, our method outperforms state-of-the-art algorithms for outbreak detection. Finally, a qualitative study of our result shows that the people and locations we select to monitor as sensors are intuitive and meaningful.Author summary: Healthcare acquired infections (HAIs) lead to significant losses of lives and result in heavy economic burden on healthcare providers worldwide. Timely detection of HAI outbreaks will have a significant impact on the health infrastructure. Here, we propose an efficient and effective approach to detect HAI outbreaks by strategically monitoring selected people and locations (sensors). Our approach leverages outbreak data generated by calibrated mechanistic simulation of C. difficile spread in a hospital wing and a careful computational formulation to determine the people and locations to monitor. Results show that our approach is effective in detecting outbreaks.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pcbi00:1007284

DOI: 10.1371/journal.pcbi.1007284

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