Stability of spontaneous, correlated activity in mouse auditory cortex

Richard F Betzel, Katherine C Wood, Christopher Angeloni, Maria Neimark Geffen and Danielle S Bassett

PLOS Computational Biology, 2019, vol. 15, issue 12, 1-25

Abstract: Neural systems can be modeled as complex networks in which neural elements are represented as nodes linked to one another through structural or functional connections. The resulting network can be analyzed using mathematical tools from network science and graph theory to quantify the system’s topological organization and to better understand its function. Here, we used two-photon calcium imaging to record spontaneous activity from the same set of cells in mouse auditory cortex over the course of several weeks. We reconstruct functional networks in which cells are linked to one another by edges weighted according to the correlation of their fluorescence traces. We show that the networks exhibit modular structure across multiple topological scales and that these multi-scale modules unfold as part of a hierarchy. We also show that, on average, network architecture becomes increasingly dissimilar over time, with similarity decaying monotonically with the distance (in time) between sessions. Finally, we show that a small fraction of cells maintain strongly-correlated activity over multiple days, forming a stable temporal core surrounded by a fluctuating and variable periphery. Our work indicates a framework for studying spontaneous activity measured by two-photon calcium imaging using computational methods and graphical models from network science. The methods are flexible and easily extended to additional datasets, opening the possibility of studying cellular level network organization of neural systems and how that organization is modulated by stimuli or altered in models of disease.Author summary: Neurons coordinate their activity with one another, forming networks that help support adaptive, flexible behavior. Still, little is known about the organization of these networks at the cellular scale and their stability over time. Here, we reconstruct networks from calcium imaging data recorded in mouse primary auditory cortex. We show that these networks exhibit spatially constrained, hierarchical modular structure, which may facilitate specialized information processing. However, we show that connection weights and modular structure are also variable over time, changing on a timescale of days and adopting novel network configurations. Despite this, a small subset of neurons maintain their connections to one another and preserve their modular organization across time, forming a stable temporal core surrounded by a flexible periphery. These findings represent a conceptual bridge linking network analyses of macroscale and cellular-level neuroimaging data. They also represent a complementary approach to existing circuits- and systems-based interrogation of nervous system function, opening the door for deeper and more targeted analysis in the future.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pcbi00:1007360

DOI: 10.1371/journal.pcbi.1007360

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