Signatures of neutral evolution in exponentially growing tumors: A theoretical perspective

Hwai-Ray Tung and Rick Durrett

PLOS Computational Biology, 2021, vol. 17, issue 2, 1-12

Abstract: Recent work of Sottoriva, Graham, and collaborators have led to the controversial claim that exponentially growing tumors have a site frequency spectrum that follows the 1/f law consistent with neutral evolution. This conclusion has been criticized based on data quality issues, statistical considerations, and simulation results. Here, we use rigorous mathematical arguments to investigate the site frequency spectrum in the two-type model of clonal evolution. If the fitnesses of the two types are λ0

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pcbi00:1008701

DOI: 10.1371/journal.pcbi.1008701

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