Beyond the chemical master equation: Stochastic chemical kinetics coupled with auxiliary processes

Davin Lunz, Gregory Batt, Jakob Ruess and J Frédéric Bonnans

PLOS Computational Biology, 2021, vol. 17, issue 7, 1-24

Abstract: The chemical master equation and its continuum approximations are indispensable tools in the modeling of chemical reaction networks. These are routinely used to capture complex nonlinear phenomena such as multimodality as well as transient events such as first-passage times, that accurately characterise a plethora of biological and chemical processes. However, some mechanisms, such as heterogeneous cellular growth or phenotypic selection at the population level, cannot be represented by the master equation and thus have been tackled separately. In this work, we propose a unifying framework that augments the chemical master equation to capture such auxiliary dynamics, and we develop and analyse a numerical solver that accurately simulates the system dynamics. We showcase these contributions by casting a diverse array of examples from the literature within this framework and applying the solver to both match and extend previous studies. Analytical calculations performed for each example validate our numerical results and benchmark the solver implementation.Author summary: Populations of genetically identical cells tend to exhibit remarkable variability. This seemingly counter-intuitive observation has broad and fascinating implications, and has thus been a focal point of biological modeling. Many important processes act on this cellular heterogeneity at the population level, leading to an intricate coupling between the single-cell and the population-level dynamics. For example, selection pressures or growth rates may depend crucially on the expression of a particular gene (or gene family). Classical single-cell modeling approaches, such as the chemical master equation, can accurately describe the mechanisms driving cellular noise, however, they cannot encapsulate how the aforementioned auxiliary processes affect the population composition. In this work, we propose a unifying framework that extends the classical chemical master equation to faithfully capture the single-cell variability alongside the population-level evolution. We develop, analyse, and showcase an open-source numerical tool to simulate the dynamics of such populations in time. The tool is designed for straightforward use by a non-technical audience: a high-level description of the underlying chemical and population-level processes suffices to simulate complex system dynamics. Simultaneously, we retain high customisability of the underlying mathematical representation for the more advanced user. Ultimately, the unifying framework and the associated computational tool open new horizons in the study of how fundamental microscopic dynamics give rise to complex macroscopic phenomena.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pcbi00:1009214

DOI: 10.1371/journal.pcbi.1009214

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