DySCo: A general framework for dynamic functional connectivity

Giuseppe de Alteriis, Oliver Sherwood, Alessandro Ciaramella, Robert Leech, Joana Cabral, Federico E Turkheimer and Paul Expert

PLOS Computational Biology, 2025, vol. 21, issue 3, 1-32

Abstract: A crucial challenge in neuroscience involves characterising brain dynamics from high-dimensional brain recordings. Dynamic Functional Connectivity (dFC) is an analysis paradigm that aims to address this challenge. dFC consists of a time-varying matrix (dFC matrix) expressing how pairwise interactions across brain areas change over time. However, the main dFC approaches have been developed and applied mostly empirically, lacking a common theoretical framework and a clear view on the interpretation of the results derived from the dFC matrices. Moreover, the dFC community has not been using the most efficient algorithms to compute and process the matrices efficiently, which has prevented dFC from showing its full potential with high-dimensional datasets and/or real-time applications. In this paper, we introduce the Dynamic Symmetric Connectivity Matrix analysis framework (DySCo), with its associated repository. DySCo is a framework that presents the most commonly used dFC measures in a common language and implements them in a computationally efficient way. This allows the study of brain activity at different spatio-temporal scales, down to the voxel level. DySCo provides a single framework that allows to: (1) Use dFC as a tool to capture the spatio-temporal interaction patterns of data in a form that is easily translatable across different imaging modalities. (2) Provide a comprehensive set of measures to quantify the properties and evolution of dFC over time: the amount of connectivity, the similarity between matrices, and their informational complexity. By using and combining the DySCo measures it is possible to perform a full dFC analysis. (3) Leverage the Temporal Covariance EVD algorithm (TCEVD) to compute and store the eigenvectors and values of the dFC matrices, and then also compute the DySCo measures from the EVD. Developing the framework in the eigenvector space is orders of magnitude faster and more memory efficient than naïve algorithms in the matrix space, without loss of information. The methodology developed here is validated on both a synthetic dataset and a rest/N-back task experimental paradigm from the fMRI Human Connectome Project dataset. We show that all the proposed measures are sensitive to changes in brain configurations and consistent across time and subjects. To illustrate the computational efficiency of the DySCo toolbox, we performed the analysis at the voxel level, a task which is computationally demanding but easily afforded by the TCEVD.Author summary: The brain transitions through a landscape of multiple dynamic configurations over time. Developing tools to study this landscape is crucial for a better understanding of the dynamic properties of the brain and to assess how they relate to cognition, behaviour, and pathologies. Dynamic Functional Connectivity (dFC) serves as a valuable tool for this purpose; However, despite its widespread use, the field has lacked a theoretical framework, optimized algorithms, and a standardized set of measures. DySCo provides a unified framework for the most commonly used dFC approaches. It develops a set of measures to quantify the properties of dFC and proposes algorithms that enable the computation and analysis of dFC with minimal computational effort. This innovation facilitates the use of dFC as a fast and efficient tool for high-dimensional datasets or real-time data. In this paper, we demonstrate the utility of DySCo by applying it to task-based fMRI data.

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pcbi00:1012795

DOI: 10.1371/journal.pcbi.1012795

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