 Expectation generation and its effect on subsequent pain and visual perceptionRotem Botvinik-Nezer, Stephan Geuter, Martin A Lindquist and Tor D Wager PLOS Computational Biology, 2025, vol. 21, issue 5, 1-30 Abstract: Bayesian accounts of perception, such as predictive processing, suggest that perceptions integrate expectations and sensory experience, and thus assimilate to expected values. Furthermore, more precise expectations should have stronger influences on perception. We tested these hypotheses using a within-subject paradigm that independently manipulated the mean, variance (precision), and skewness of cues presented as ratings from 10 prior participants. Forty-five participants reported their expectations regarding the painfulness of thermal stimuli or the visual contrast of flickering checkerboards. In a second session, similar (sham) cues were each followed by either a noxious thermal or a visual stimulus. Perceptions assimilated to cue-based expectations in both modalities, but precision effects were modality-specific: more precise cues enhanced assimilation in visual perception only, while higher uncertainty slightly increased reported pain. fMRI analysis revealed that the cues affected higher-level affective and cognitive systems–including assimilation to the cue mean in a neuromarker of endogenous pain processing and in the nucleus accumbens, and activity consistent with aversive prediction-error-like encoding in the periaqueductal gray during pain perception–but not early perceptual processing systems. Furthermore, behavioral and computational models of the expectation session revealed that expectations were biased towards extreme values in both modalities, and towards low-pain cues specifically. These findings suggest that predictive processing theories should be extended with mechanisms such as selective attention to outliers, and that expectation generation and its perceptual effects are mostly modality-specific and primarily influence higher-level processes rather than early perception, at least when cues are not reinforced.Author summary: Expectations shape how we perceive the world, influencing both what we feel and what we see. But how do we form these expectations, and how do they affect our perception? We investigated how people generate expectations about upcoming pain and visual stimuli based on complex multi-attribute social cues—ratings of 10 other participants—and how these expectations influence perception and brain activity. Using behavioral experiments and computational modeling, we found that people rely heavily on an average summary of complex cue features when forming expectations, but extreme values also play a role, especially in lowering pain expectations when signaling lower pain. Perceptual judgments in both modalities tended to shift toward expected values, but the uncertainty of these expectations affected perception in different ways across pain and vision, and were only consistent with precision-weighted integration of cue information posited by predictive processing accounts in vision. Our neural findings suggest that expectations do not directly alter early sensory processing but instead shape how information is interpreted at later decision-making stages. These insights enhance our understanding of how the brain integrates contextual cues and may inform better approaches to pain management and sensory disorders. Date: 2025 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:plo:pcbi00:1013053 DOI: 10.1371/journal.pcbi.1013053 Access Statistics for this article More articles in PLOS Computational Biology from Public Library of Science |
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