PLOS Genetics
2005 - 2025
From Public Library of Science Bibliographic data for series maintained by plosgenetics (). Access Statistics for this journal.
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Volume 21, issue 9, 2025
- Genome-wide association study provides novel insight into the genetic architecture of severe obesity pp. 1-27

- Mohanraj Krishnan, Mohammad Yaser Anwar, Anne E Justice, Geetha Chittoor, Hung-Hsin Chen, Rashedeh Roshani, Alyssa Scartozzi, Rachel R Dickerson, Roelof A J Smit, Michael H Preuss, Nathalie Chami, Benjamin S Hadad, Esteban J Parra, Miguel Cruz, Qin Hui, Peter W F Wilson, Yan V Sun, Xiaoyu Zhang, Gregorio V Linchangco, Sharon L R Kardia, Jessica D Faul, David R Weir, Lawrence F Bielak, Heather M Highland, Kristin L Young, Baiyu Qi, Yujie Wang, Myriam Fornage, Christopher Haiman, Iona Cheng, Ulrike Peters, Charles Kooperberg, Steven Buyske, Joseph B McCormick, Susan P Fisher-Hoch, Frida Lona-Durazo, Jesus Peralta, Jamie Gomez-Zamudio, Stephen S Rich, Kendra R Ferrier, Ethan M Lange, Christopher R Gignoux, Eimear E Kenny, Genevieve L Wojcik, Kelly Cho, Michael J Gaziano, Luc Djousse, Shuwei Liu, Dhananjay Vaidya, Renée de Mutsert, Navya S Josyula, Christopher R Bauer, Wei Zhao, Ryan W Walker, Jennifer A Smith, Leslie A Lange, Mariah C Meyer, Ching-Ti Liu, Lisa R Yanek, Miryoung Lee, Laura M Raffield, Ruth J F Loos, Penny Gordon-Larsen, Jennifer E Below, Kari E North and Mariaelisa Graff
- Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP7 in land plants pp. 1-35

- Ranjana Yadav, Guizhen Liu, Priyanshi Rana, Naga Jyothi Pullagurla, Danye Qiu, Henning J Jessen and Debabrata Laha
Volume 21, issue 8, 2025
- Gene dosage and protein valency impact phase separation and fungal cell fate pp. 1-33

- Collin Ganser, Peiling He, Corey Frazer, Damian J Krysan and Richard J Bennett
- Detecting latent interaction effects when analyzing binary traits pp. 1-17

- Ziang Zhang, Jerald F Lawless, Andrew D Paterson and Lei Sun
- Understanding the alcohol harm paradox: A multivariable mendelian randomization approach pp. 1-15

- Gemma Sawyer, Hannah Sallis, Marcus Munafò, Liam Mahedy and Jasmine Khouja
Volume 21, issue 7, 2025
- Genomic organization, domain assortments, and nucleotide-binding domain diversity of NLR proteins in Sordariales fungi pp. 1-28

- Lucas Bonometti, Florian Charriat, Noah Hensen, Silvia Miñana-Posada, Hanna Johannesson and Pierre Gladieux
- Systematically identification of survival-associated eQTLs in a Japanese kidney cancer cohort pp. 1-28

- Xiya Song, Han Jin, Xiangyu Li, Meng Yuan, Hong Yang, Yusuke Sato, Haruki Kume, Seishi Ogawa, Cheng Zhang and Adil Mardinoglu
- Genetic and environmental influences on the distributions of three chromosomal drive haplotypes in maize pp. 1-19

- Meghan J Brady and R Kelly Dawe
- Expectations for papers performing Mendelian randomization analyses pp. 1-4

- Scott M Williams, Hua Tang, Gregory M Cooper, Anne O’Donnell-Luria, Santhosh Girirajan, Aimée M Dudley, Anne Goriely, Zoltán Kutalik, Xiaofeng Zhu, Giorgio Sirugo and Michael P Epstein
- A novel expectation-maximization approach to infer general diploid selection from time-series genetic data pp. 1-38

- Adam G Fine and Matthias Steinrücken
Volume 21, issue 6, 2025
- Environmental data provide marginal benefit for predicting climate adaptation pp. 1-31

- Forrest Li, Daniel J Gates, Edward S Buckler, Matthew B Hufford, Garrett M Janzen, Rubén Rellán-Álvarez, Fausto Rodríguez-Zapata, J Alberto Romero Navarro, Ruairidh J H Sawers, Samantha J Snodgrass, Kai Sonder, Martha C Willcox, Sarah J Hearne, Jeffrey Ross-Ibarra and Daniel E Runcie
- Defining the high-translational readthrough stop codon context pp. 1-17

- Daniela Smoljanow, Dennis Lebeda, Julia Hofhuis and Sven Thoms
Volume 21, issue 4, 2025
- Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes pp. 1-33

- Yuriko Harigaya, Nana Matoba, Brandon D Le, Jordan M Valone, Jason L Stein, Michael I Love and William Valdar
- Probing the limits of cis-acting gene regulation using a model of allelic imbalance quantitative trait loci pp. 1-19

- Cathal Seoighe, Seán Connaire and Mehak Chopra
Volume 21, issue 3, 2025
- Haplotype-based analysis distinguishes maternal-fetal genetic contribution to pregnancy-related outcomes pp. 1-33

- Amit K Srivastava, Julius Juodakis, Pol Sole-Navais, Jing Chen, Jonas Bacelis, Kari Teramo, Mikko Hallman, Pal R Njølstad, David M Evans, Bo Jacobsson, Louis J Muglia and Ge Zhang
- Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s Disease pp. 1-16

- Nicholas R Ray, Joseph Bradley, Elanur Yilmaz, Caghan Kizil, Jiji T Kurup, Eden R Martin, Hans-Ulrich Klein, Brian W Kunkle, David A Bennett, Philip L De Jager, Alzheimer’s Disease Genetics Consortium, Gary W Beecham, Carlos Cruchaga and Christiane Reitz
- RatXcan: A framework for cross-species integration of genome-wide association and gene expression data pp. 1-18

- Natasha Santhanam, Sandra Sanchez-Roige, Sabrina Mi, Yanyu Liang, Apurva S Chitre, Daniel Munro, Denghui Chen, Jianjun Gao, Angel Garcia-Martinez, Anthony M George, Alexander F Gileta, Wenyan Han, Katie Holl, Alesa Hughson, Christopher P King, Alexander C Lamparelli, Connor D Martin, Festus Nyasimi, Celine L St. Pierre, Sarah Sumner, Jordan Tripi, Tengfei Wang, Hao Chen, Shelly Flagel, Keita Ishiwari, Paul Meyer, Oksana Polesskaya, Laura Saba, Leah C Solberg Woods, Abraham A Palmer and Hae Kyung Im
Volume 21, issue 2, 2025
- Two transmembrane transcriptional regulators coordinate to activate chitin-induced natural transformation in Vibrio cholerae pp. 1-20

- Allison C Hullinger, Virginia E Green, Catherine A Klancher, Triana N Dalia and Ankur B Dalia
Volume 21, issue 1, 2025
- metaGE: Investigating genotype x environment interactions through GWAS meta-analysis pp. 1-26

- Annaïg De Walsche, Alexis Vergne, Renaud Rincent, Fabrice Roux, Stéphane Nicolas, Claude Welcker, Sofiane Mezmouk, Alain Charcosset and Tristan Mary-Huard
- Estimating evolutionary and demographic parameters via ARG-derived IBD pp. 1-16

- Zhendong Huang, Jerome Kelleher, Yao-ban Chan and David Balding
- ADELLE: A global testing method for trans-eQTL mapping pp. 1-22

- Takintayo Akinbiyi, Mary Sara McPeek and Mark Abney
- Refining fine-mapping: Effect sizes and regional heritability pp. 1-21

- Christian Benner, Anubha Mahajan and Matti Pirinen
Volume 20, issue 12, 2024
- Adjusting for principal components can induce collider bias in genome-wide association studies pp. 1-29

- Kelsey E Grinde, Brian L Browning, Alexander P Reiner, Timothy A Thornton and Sharon R Browning
- Disentangling the consequences of type 2 diabetes on targeted metabolite profiles using causal inference and interaction QTL analyses pp. 1-20

- Ozvan Bocher, Archit Singh, Yue Huang, Urmo Võsa, Ene Reimann, Ana Arruda, Andrei Barysenska, Anastassia Kolde, Nigel W Rayner, Estonian Biobank research Team, Tõnu Esko, Reedik Mägi and Eleftheria Zeggini
- FABIO: TWAS fine-mapping to prioritize causal genes for binary traits pp. 1-26

- Haihan Zhang, Kevin He, Zheng Li, Lam C Tsoi and Xiang Zhou
- Integrin adhesome axis inhibits the RPM-1 ubiquitin ligase signaling hub to regulate growth cone and axon development pp. 1-30

- Jonathan Amezquita, Muriel Desbois, Karla J Opperman, Joseph S Pak, Elyse L Christensen, Nikki T Nguyen, Karen Diaz-Garcia, Melissa A Borgen and Brock Grill
Volume 20, issue 11, 2024
- Prediction of causal genes at GWAS loci with pleiotropic gene regulatory effects using sets of correlated instrumental variables pp. 1-29

- Mariyam Khan, Adriaan-Alexander Ludl, Sean Bankier, Johan L M Björkegren and Tom Michoel
- A novel statistical framework for meta-analysis of total mediation effect with high-dimensional omics mediators in large-scale genomic consortia pp. 1-23

- Zhichao Xu and Peng Wei
Volume 20, issue 10, 2024
- STAREG: Statistical replicability analysis of high throughput experiments with applications to spatial transcriptomic studies pp. 1-19

- Yan Li, Xiang Zhou, Rui Chen, Xianyang Zhang and Hongyuan Cao
- Dual role for Headcase in hemocyte progenitor fate determination in Drosophila melanogaster pp. 1-25

- Bayan Kharrat, Erika Gábor, Nikolett Virág, Rita Sinka, Ferenc Jankovics, Ildikó Kristó, Péter Vilmos, Gábor Csordás and Viktor Honti
Volume 20, issue 9, 2024
- MR-SPLIT: A novel method to address selection and weak instrument bias in one-sample Mendelian randomization studies pp. 1-23

- Ruxin Shi, Ling Wang, Stephen Burgess and Yuehua Cui
- Upstream open reading frames repress the translation from the iab-8 RNA pp. 1-18

- Yohan Frei, Clément Immarigeon, Maxime Revel, François Karch and Robert K Maeda
- Constraining models of dominance for nonsynonymous mutations in the human genome pp. 1-25

- Christopher C Kyriazis and Kirk E Lohmueller
- Prioritizing disease-related rare variants by integrating gene expression data pp. 1-16

- Hanmin Guo, Alexander Eckehart Urban and Wing Hung Wong
Volume 20, issue 8, 2024
- Finemap-MiXeR: A variational Bayesian approach for genetic finemapping pp. 1-21

- Bayram Cevdet Akdeniz, Oleksandr Frei, Alexey Shadrin, Dmitry Vetrov, Dmitry Kropotov, Eivind Hovig, Ole A Andreassen and Anders M Dale
- Enhancing portability of trans-ancestral polygenic risk scores through tissue-specific functional genomic data integration pp. 1-18

- Bradley Crone and Alan P Boyle
Volume 20, issue 7, 2024
- Improving population scale statistical phasing with whole-genome sequencing data pp. 1-22

- Rick Wertenbroek, Robin J Hofmeister, Ioannis Xenarios, Yann Thoma and Olivier Delaneau
Volume 20, issue 6, 2024
- TGF-β ligand cross-subfamily interactions in the response of Caenorhabditis elegans to a bacterial pathogen pp. 1-20

- Emma Jo Ciccarelli, Zachary Wing, Moshe Bendelstein, Ramandeep Kaur Johal, Gurjot Singh, Ayelet Monas and Cathy Savage-Dunn
Volume 20, issue 5, 2024
- Simultaneous estimation of genotype error and uncalled deletion rates in whole genome sequence data pp. 1-18

- Nobuaki Masaki, Sharon R Browning and Brian L Browning
- Transcription decouples estrogen-dependent changes in enhancer-promoter contact frequencies and spatial proximity pp. 1-27

- Luciana I Gómez Acuña, Ilya Flyamer, Shelagh Boyle, Elias T Friman and Wendy A Bickmore
Volume 20, issue 4, 2024
- Better together against genetic heterogeneity: A sex-combined joint main and interaction analysis of 290 quantitative traits in the UK Biobank pp. 1-23

- Boxi Lin, Andrew D Paterson and Lei Sun
- Collider bias correction for multiple covariates in GWAS using robust multivariable Mendelian randomization pp. 1-27

- Peiyao Wang, Zhaotong Lin, Haoran Xue and Wei Pan
- Correlation-based tests for the formal comparison of polygenic scores in multiple populations pp. 1-17

- Sophia Gunn and Kathryn L Lunetta
Volume 20, issue 3, 2024
- Canadian COVID-19 host genetics cohort replicates known severity associations pp. 1-25

- Elika Garg, Paola Arguello-Pascualli, Olga Vishnyakova, Anat R Halevy, Samantha Yoo, Jennifer D Brooks, Shelley B Bull, France Gagnon, Celia M T Greenwood, Rayjean J Hung, Jerald F Lawless, Jordan Lerner-Ellis, Jessica K Dennis, Rohan J S Abraham, Jean-Michel Garant, Bhooma Thiruvahindrapuram, Steven J M Jones, CGEn HostSeq Initiative, Lisa J Strug, Andrew D Paterson, Lei Sun and Lloyd T Elliott
Volume 20, issue 2, 2024
- Maintenance of proteostasis by Drosophila Rer1 is essential for competitive cell survival and Myc-driven overgrowth pp. 1-28

- Pranab Kumar Paul, Shruti Umarvaish, Shivani Bajaj, Rishana Farin S., Hrudya Mohan, Wim Annaert and Varun Chaudhary
- TRAILS: Tree reconstruction of ancestry using incomplete lineage sorting pp. 1-21

- Iker Rivas-González, Mikkel H Schierup, John Wakeley and Asger Hobolth
Volume 19, issue 12, 2023
- FiMAP: A fast identity-by-descent mapping test for biobank-scale cohorts pp. 1-20

- Han Chen, Ardalan Naseri and Degui Zhi
- Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks pp. 1-28

- Lars G Fritsche, Kisung Nam, Jiacong Du, Ritoban Kundu, Maxwell Salvatore, Xu Shi, Seunggeun Lee, Stephen Burgess and Bhramar Mukherjee
- cLD: Rare-variant linkage disequilibrium between genomic regions identifies novel genomic interactions pp. 1-21

- Dinghao Wang, Deshan Perera, Jingni He, Chen Cao, Pathum Kossinna, Qing Li, William Zhang, Xingyi Guo, Alexander Platt, Jingjing Wu and Qingrun Zhang
Volume 19, issue 11, 2023
- Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons pp. 1-26

- Dylan Clark-Boucher, Xiang Zhou, Jiacong Du, Yongmei Liu, Belinda L Needham, Jennifer A Smith and Bhramar Mukherjee
- Phosphorylation of AHR by PLK1 promotes metastasis of LUAD via DIO2-TH signaling pp. 1-27

- Chaohao Li, Derek B Allison, Daheng He, Fengyi Mao, Xinyi Wang, Piotr Rychahou, Ibrahim A Imam, Yifan Kong, Qiongsi Zhang, Yanquan Zhang, Jinghui Liu, Ruixin Wang, Xiongjian Rao, Sai Wu, B Mark Evers, Qing Shao, Chi Wang, Zhiguo Li and Xiaoqi Liu
- Inferring multi-locus selection in admixed populations pp. 1-27

- Nicolas M Ayala, Maximilian Genetti and Russell Corbett-Detig
- Transfer learning with false negative control improves polygenic risk prediction pp. 1-17

- Xinge Jessie Jeng, Yifei Hu, Vaishnavi Venkat, Tzu-Pin Lu and Jung-Ying Tzeng
- BRASS: Permutation methods for binary traits in genetic association studies with structured samples pp. 1-21

- Joelle Mbatchou, Mark Abney and Mary Sara McPeek
Volume 19, issue 10, 2023
- Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci pp. 1-19

- Anu Pasanen, Minna K Karjalainen, FinnGen, Ge Zhang, Heli Tiensuu, Antti M Haapalainen, Marja Ojaniemi, Bjarke Feenstra, Bo Jacobsson, Aarno Palotie, Hannele Laivuori, Louis J Muglia, Mika Rämet and Mikko Hallman
- SMASH: Scalable Method for Analyzing Spatial Heterogeneity of genes in spatial transcriptomics data pp. 1-25

- Souvik Seal, Benjamin G Bitler and Debashis Ghosh
Volume 19, issue 9, 2023
- Review and further developments in statistical corrections for Winner’s Curse in genetic association studies pp. 1-29

- Amanda Forde, Gibran Hemani and John Ferguson
- Saturation genome editing of 11 codons and exon 13 of BRCA2 coupled with chemotherapeutic drug response accurately determines pathogenicity of variants pp. 1-28

- Sounak Sahu, Teresa L Sullivan, Alexander Y Mitrophanov, Mélissa Galloux, Darryl Nousome, Eileen Southon, Dylan Caylor, Arun Prakash Mishra, Christine N Evans, Michelle E Clapp, Sandra Burkett, Tyler Malys, Raj Chari, Kajal Biswas and Shyam K Sharan
- Inferring gene regulatory network from single-cell transcriptomes with graph autoencoder model pp. 1-28

- Jiacheng Wang, Yaojia Chen and Quan Zou
- Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer pp. 1-13

- Jingxiong Xu, Wei Xu, Jiyeon Choi, Yonathan Brhane, David C Christiani, Jui Kothari, James McKay, John K Field, Michael P A Davies, Geoffrey Liu, Christopher I Amos, Rayjean J Hung and Laurent Briollais
- On the interpretation of transcriptome-wide association studies pp. 1-23

- Christiaan de Leeuw, Josefin Werme, Jeanne E Savage, Wouter J Peyrot and Danielle Posthuma
- Evolutionary conserved circular MEF2A RNAs regulate myogenic differentiation and skeletal muscle development pp. 1-32

- Xiaoxu Shen, Xiyu Zhao, Haorong He, Jing Zhao, Yuanhang Wei, Yuqi Chen, Shunshun Han, Yifeng Zhu, Yao Zhang, Qing Zhu and Huadong Yin
Volume 19, issue 8, 2023
- Accurate detection of shared genetic architecture from GWAS summary statistics in the small-sample context pp. 1-19

- Thomas W Willis and Chris Wallace
Volume 19, issue 7, 2023
- A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled pp. 1-26

- Ashley C Humphries, Claudia Molina-Pelayo, Parijat Sil, C Clayton Hazelett, Danelle Devenport and Marek Mlodzik
- A genetic tradeoff for tolerance to moderate and severe heat stress in US hybrid maize pp. 1-29

- Aaron Kusmec, Lakshmi Attigala, Xiongtao Dai, Srikant Srinivasan, Cheng-Ting “Eddy” Yeh and Patrick S Schnable
- Organization and replicon interactions within the highly segmented genome of Borrelia burgdorferi pp. 1-27

- Zhongqing Ren, Constantin N Takacs, Hugo B Brandão, Christine Jacobs-Wagner and Xindan Wang
- Regularized sequence-context mutational trees capture variation in mutation rates across the human genome pp. 1-22

- Christopher J Adams, Mitchell Conery, Benjamin J Auerbach, Shane T Jensen, Iain Mathieson and Benjamin F Voight
- A flexible empirical Bayes approach to multivariate multiple regression, and its improved accuracy in predicting multi-tissue gene expression from genotypes pp. 1-21

- Fabio Morgante, Peter Carbonetto, Gao Wang, Yuxin Zou, Abhishek Sarkar and Matthew Stephens
Volume 19, issue 6, 2023
- Relaxing parametric assumptions for non-linear Mendelian randomization using a doubly-ranked stratification method pp. 1-22

- Haodong Tian, Amy M Mason, Cunhao Liu and Stephen Burgess
- Combinations of genes at the 16p11.2 and 22q11.2 CNVs contribute to neurobehavioral traits pp. 1-20

- Mikhail Vysotskiy, Autism Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium and Lauren A Weiss
Volume 19, issue 5, 2023
- Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits pp. 1-32

- Luke M Evans, Christopher H Arehart, Andrew D Grotzinger, Travis J Mize, Maizy S Brasher, Jerry A Stitzel, Marissa A Ehringer and Charles A Hoeffer
- The molecular mechanism for carbon catabolite repression of the chitin response in Vibrio cholerae pp. 1-26

- Virginia E Green, Catherine A Klancher, Shouji Yamamoto and Ankur B Dalia
Volume 19, issue 4, 2023
- Imputed genomes and haplotype-based analyses of the Picts of early medieval Scotland reveal fine-scale relatedness between Iron Age, early medieval and the modern people of the UK pp. 1-25

- Adeline Morez, Kate Britton, Gordon Noble, Torsten Günther, Anders Götherström, Ricardo Rodríguez-Varela, Natalija Kashuba, Rui Martiniano, Sahra Talamo, Nicholas J Evans, Joel D Irish, Christina Donald and Linus Girdland-Flink
Volume 19, issue 3, 2023
- Tuberculosis severity associates with variants and eQTLs related to vascular biology and infection-induced inflammation pp. 1-25

- Michael L McHenry, Jason Simmons, Hyejeong Hong, LaShaunda L Malone, Harriet Mayanja-Kizza, William S Bush, W Henry Boom, Thomas R Hawn, Scott M Williams and Catherine M Stein
Volume 19, issue 2, 2023
- The identification of mediating effects using genome-based restricted maximum likelihood estimation pp. 1-17

- Cornelius A Rietveld, Ronald de Vlaming and Eric A W Slob
- Bayesian inference of admixture graphs on Native American and Arctic populations pp. 1-22

- Svend V Nielsen, Andrew H Vaughn, Kalle Leppälä, Michael J Landis, Thomas Mailund and Rasmus Nielsen
Volume 19, issue 1, 2023
- Historic samples reveal loss of wild genotype through domestic chicken introgression during the Anthropocene pp. 1-19

- Meng Yue Wu, Giovanni Forcina, Gabriel Weijie Low, Keren R Sadanandan, Chyi Yin Gwee, Hein van Grouw, Shaoyuan Wu, Scott V Edwards, Maude W Baldwin and Frank E Rheindt
- Decomposing heritability and genetic covariance by direct and indirect effect paths pp. 1-17

- Jie Song, Yiqing Zou, Yuchang Wu, Jiacheng Miao, Ze Yu, Jason Fletcher and Qiongshi Lu
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