HIV-1 integrase resistance associated mutations and the use of dolutegravir in Sub-Saharan Africa: A systematic review and meta-analysis

Ezechiel Ngoufack Jagni Semengue, Maria Mercedes Santoro, Valantine Ngum Ndze, Aude Christelle Ka’e, Bouba Yagai, Alex Durand Nka, Beatrice Dambaya, Desiré Takou, Georges Teto, Lavinia Fabeni, Vittorio Colizzi, Carlo-Federico Perno, Francesca Ceccherini-Silberstein and Joseph Fokam

PLOS Global Public Health, 2022, vol. 2, issue 10, 1-19

Abstract: As sub-Saharan Africa (SSA) countries are transitioning to dolutegravir (DTG)-based ART, baseline data are required for optimal monitoring of therapeutic response. In this frame, we sought to generate up-to-date evidence on the use of integrase-strand transfer inhibitors (INSTI) and associated drug resistance mutations (DRMs) within SSA. In this systematic review and meta-analysis, we included randomized and non-randomized trials, cohort-studies, cross-sectional studies, and case-reports published on INSTI or integrase DRMs in SSA. We included studies of patients exposed to DTG, raltegravir (RAL) or elvitegravir (EVG). Primary outcomes were “the rate of virological control (VC:

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgph00:0000826

DOI: 10.1371/journal.pgph.0000826

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