The global burden of high fasting plasma glucose associated with zinc deficiency: Results of a systematic review and meta-analysis

James P Wirth, Wu Zeng, Nicolai Petry, Fabian Rohner, Scott Glenn, William E S Donkor, Rita Wegmüller, Erick Boy and Keith Lividini

PLOS Global Public Health, 2023, vol. 3, issue 3, 1-22

Abstract: Non-communicable diseases (NCDs) account for the largest share of the global disease burden, and increasing evidence shows that zinc deficiency (ZD) contributes to NCDs by inducing oxidative stress, insulin resistance, and impaired lipid metabolism. A systematic review and meta-analysis was conducted to determine whether ZD was associated with fasting plasma glucose (FPG), a key risk factor for NCDs. A random effects meta-analysis was conducted to determine the strength of the association in the form of an odds ratio (OR) and subsequently the population attributable risk (PAR) with population prevalences of high FPG. The disease burden from high FPG attributable to ZD was expressed as disability adjusted life years (DALYS). Data from seven studies were obtained as part of the systematic review. The meta-analysis shows a significant (p

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgph00:0001353

DOI: 10.1371/journal.pgph.0001353

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