Characterisation of populations at risk of sub-optimal dosing of artemisinin-based combination therapy in Africa

Abena Takyi, Verena I Carrara, Prabin Dahal, Marianna Przybylska, Eli Harriss, Genevieve Insaidoo, Karen I Barnes, Philippe J Guerin and Kasia Stepniewska

PLOS Global Public Health, 2023, vol. 3, issue 12, 1-17

Abstract: Selection of resistant malaria strains occurs when parasites are exposed to inadequate antimalarial drug concentrations. The proportion of uncomplicated falciparum malaria patients at risk of being sub-optimally dosed with the current World Health Organization (WHO) recommended artemisinin-based combination therapies (ACTs) is unknown. This study aims to estimate this proportion and the excess number of treatment failures (recrudescences) associated with sub-optimal dosing in Sub-Saharan Africa. Sub-populations at risk of sub-optimal dosing include wasted children

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgph00:0002059

DOI: 10.1371/journal.pgph.0002059

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