A randomised survey of the quality of antibiotics and other essential medicines in Indonesia, with volume-adjusted estimates of the prevalence of substandard medicines

Elizabeth Pisani, Ayu Rahmawati, Esti Mulatsari, Mawaddati Rahmi, William Nathanial, Yusi Anggriani and on behalf of the STARmeds Study Group

PLOS Global Public Health, 2024, vol. 4, issue 12, 1-17

Abstract: The World Health Organization warns that substandard and falsified medicines threaten public health in low- and middle-income countries. However, medicine quality surveys are often small and unrepresentative of the market, and the true scale of the problem remains unknown. We conducted a large field survey of essential medicines in Indonesia, and investigated how weighting survey results by market volume altered estimates of medicine quality. We collected 1274 samples of allopurinol, amlodipine, cefixime, amoxicillin and dexamethasone from the internet and a randomised sample of all outlet-types where medicines are sold or dispensed in seven districts across the world’s fourth most populous nation. We conducted compendial testing for identity, assay, dissolution and uniformity. Samples that failed any chemical test were considered substandard. We compared raw prevalence of substandard medicines with prevalence adjusted by the national sales volume of each brand, relative to its weight among survey samples. The weighted prevalence of substandard products was 4.4%, 47% lower than the raw estimate (8.2%). Only 0.5% of samples (unweighted 1.2%) deviated from permitted limits by more than 10%. More antibiotics failed testing than other medicines (weighted prevalence 8.5 vs 3.1; raw prevalence 13.6 vs 4.9, both p

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgph00:0003999

DOI: 10.1371/journal.pgph.0003999

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