Implementation of basic package of care improved socio-economic conditions of lymphedema patients in rural Mali after two years follow-up

Housseini Dolo, Diadje Tanapo, Sekou Oumarou Thera, Moussa Sangaré, Abdoul Fatao Diabaté, Lamine Diarra, Salif Sériba Doumbia, Siaka Yamoussa Coulibaly, Ilo Dicko, Oumar Coulibaly, Ousmane Faye, Hamadoun Sangho, Seydou Doumbia, Yaya Ibrahim Coulibaly and Thomas B Nutman

PLOS Global Public Health, 2025, vol. 5, issue 11, 1-11

Abstract: Research shows that a local hygiene package washing, wound care, and exercise improves lymphedema (LE) patients’ quality of life by reducing ADLA, costs, stigma, and boosting work capacity. The ‘LEdoxy’ study, a 24-month, multicountry, double-blind, randomized controlled trial of doxycycline plus hygiene, investigated the efficacy of daily doxycycline versus a placebo for lymphatic filariasis in Mali, India, and Sri Lanka. All ‘LEdoxy’ participants consistently followed a standardized hygiene program. This study, embedded within the previous ‘LEdoxy’ study, assessed cost reductions in ADLA management and evaluated the social impact of the regular local care based on the HP among LE patients in Mali. We conducted a cross-sectional study embedded in “LEdoxy” study participants in the health districts of Kolondieba and Kolokani from September to December 2021. Questionnaire was used to collect retrospective data on pre-trial conditions and prospective data on post-trial conditions. Data were collected using a digital questionnaire and qualitative methods, including in-depth interviews and focus group discussions with interview guide, without recycling ‘LEDoxy’ data. These quantitative data were analysed using SPSS version 25.0. We performed a thematic analysis approach using Quirkos version 2. We investigated 196 LE patients with a median age of 56 years [range: 25-70 years]. We observed a reduction in the monthly frequency of acute ADLA from 90.8% (178/196) before the trial to 43.9%, (86/196) after the trial (p

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgph00:0005454

DOI: 10.1371/journal.pgph.0005454

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