PLOS Medicine

2004 - 2025

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Volume 22, issue 12, 2025

Setting the standard for high-quality studies using open health datasets pp. 1-4

Andreia Cunha, Suzanne de Bruijn, Alison Farrell, Helen Lumbard, Alexandra Tosun and Daniel Routledge

Volume 22, issue 11, 2025

The impact of adherence on colorectal cancer screening cost-effectiveness: A modeling study pp. 1-16

Jiaxin Xie, Xuesi Dong, Zilin Luo, Chenran Wang, Yadi Zheng, Xiaolu Chen, Zeming Guo, Xiaoyue Shi, Fei Wang, Wei Cao, Yongjie Xu, Le Wang, Weimiao Wu, Dong Hang, Lingbin Du and Ni Li

Financial risk protection from vaccines in 52 Gavi-eligible low- and middle-income countries: A modeling study pp. 1-17

Boshen Jiao, Ryoko Sato, Joshua Mak, Bryan Patenaude, Margaret de Villiers, Aniruddha Deshpande, Ivane Gamkrelidze, Katy A M Gaythorpe, Timothy B Hallett, Mark Jit, Xiang Li, Benjamin Lopman, Shevanthi Nayagam, Devin Razavi-Shearer, Yvonne Tam, Kim H Woodruff, Daniel Hogan, Tewodaj Mengistu and Stéphane Verguet

How can middle-income countries successfully transition away from international health aid? pp. 1-5

Osondu Ogbuoji, Ipchita Bharali, Justice Nonvignon and Gavin Yamey

From dependence to self-reliance: The future of the global tuberculosis response pp. 1-4

Petra Heitkamp, Obioma Chijioke-Akaniro and Madhukar Pai

Global Burden of Disease 2023: Challenges and opportunities for a growing collaboration pp. 1-4

Zulfiqar A Bhutta

Volume 22, issue 10, 2025

Estimating the effect on obesity of delaying tax-based interventions in Mexico: A modeling study pp. 1-13

Martha Carnalla, Francisco Reyes-Sánchez, Alexis Alonso-Bastida, Alan Reyes-García, Alessio Hernández-Rojas, C Gabriela García, Isabel Junquera-Badilla, Ana Basto-Abreu, Boyd Swimburn, Juan A Rivera and Tonatiuh Barrientos-Gutiérrez

Effectiveness of a brief intervention and text-based booster in the emergency department to reduce harmful and hazardous alcohol use: A pragmatic randomized adaptive clinical trial in Moshi, Tanzania pp. 1-18

Catherine A Staton, Linda Minja, Joao Vitor Perez de Souza, John A Gallis, Pollyana Coelho Pessoa Santos, Mia Buono, Francis Sakita, Kennedy Ngowi, Judith Boshe, Ashley J Phillips, Joao Ricardo Nickenig Vissoci and Blandina T Mmbaga

Associations between epileptic seizures in pregnancy and adverse pregnancy outcomes: A systematic review and meta-analysis pp. 1-14

Oladipupo Olalere, Saba Tariq, Olanike Ajijola, Min-Dee Koh, Katie Crabb, Amie Wilson, Anwesa Chatterjee, Mairead Black, Katie Morris, Matthew Bluett-Duncan, Emily Taylor, Sereena Raju, Fatima Junaid, Rebecca Bromley, Ngawai Moss, Marta Garcia-Finana, John Craig, Amanda Wood, Annalise Weckesser, Judith Dyson, Catherine Nelson-Piercy, Elaine Denny, Tracy Roberts, Rachel McNeill, Shakila Thangaratinam and John Allotey

Volume 22, issue 9, 2025

Comparative safety and effectiveness of apixaban and rivaroxaban for treatment of cancer-associated venous thromboembolism: A retrospective cohort study pp. 1-16

Jingjing Sun, Hemalkumar B Mehta, Jodi B Segal and G Caleb Alexander

Carbon footprint of the Chinese healthcare service: An environmentally extended input–output analysis pp. 1-17

Juan Liang, Rui Wu, Peng Bi, Shi-Lu Tong, Rui Zhang, Xiao-Yuan Yao, Xin Jin and Yong-Hong Li

Whose burden, whose benefit? Revisiting ethical trade-offs in the WHO guidelines on scaling up mass azithromycin administration pp. 1-10

Maple Goh, A M Viens, Safura Abdool Karim, Aaron S Kesselheim and Kevin Outterson

Hypertensive disorders of pregnancy and childhood neurodevelopment: A systematic review and meta-analysis pp. 1-22

Jessica A Atkinson, Hannah G Gordon, Stephen Tong, Susan P Walker, Parinaz Mehdipour, Anthea C Lindquist and Roxanne M Hastie

Machine learning algorithms and their predictive accuracy for suicide and self-harm: Systematic review and meta-analysis pp. 1-23

Matthew J Spittal, Xianglin Aneta Guo, Laurant Kang, Olivia J Kirtley, Angela Clapperton, Keith Hawton, Nav Kapur, Jane Pirkis and Greg Carter

Cyclone exposure and mortality risk of children under 5 years old: An observational study in 34 low- and middle-income countries pp. 1-18

Yichen Guo, Yixiang Zhu, Cheng He, Ya Gao, Lu Zhou, Jovine Bachwenkizi, Haidong Kan and Renjie Chen

Volume 22, issue 8, 2025

Reductions in development assistance for health funding threaten decades of progress in Africa pp. 1-3

Peter MacPherson, Marriott Nliwasa and Augustine T Choko

Predicting knee osteoarthritis progression using neural network with longitudinal MRI radiomics, and biochemical biomarkers: A modeling study pp. 1-25

Ting Wang, Hao Liu, Wenbo Zhao, Peihua Cao, Jia Li, Tianyu Chen, Guangfeng Ruan, Yan Zhang, Xiaoshuai Wang, Qin Dang, Mengdi Zhang, Alexander Tack, David Hunter, Changhai Ding and Shengfa Li

Deep brain stimulation surgical timing, outcomes, and prognostic factors in patients with Parkinson’s disease: A Chinese retrospective multicenter cohort study pp. 1-25

Shu Wang, Wei Hu, Yuan Gao, Anxin Wang, Ling Chen, Zhanhua Liang, Shizhong Zhang, Hao Long, Weiguo Li, Chaoshi Niu, Weiguo Liu, Guoen Cai, Yuchen Ji, Joseph Tam, Qin Xu, Anchao Yang, Lin Shi, Hua Zhang, Chunlei Han, Guanyu Zhu, Yutong Bai, Lulu Jiang, Tao Li, Shan Xue, Hongxiao Wang, Yuexuan Li, Chi Xiong, Andres M Lozano, Adolfo Ramirez-Zamora, Wenbin Zhang, Fangang Meng, Jianguo Zhang and Collaboration Dbs-Pdcc2

The transmission blocking activity of artemisinin-combination, non-artemisinin, and 8-aminoquinoline antimalarial therapies: A pooled analysis of individual participant data pp. 1-25

Leen N Vanheer, Jordache Ramjith, Almahamoudou Mahamar, Merel J Smit, Kjerstin Lanke, Michelle E Roh, Koualy Sanogo, Youssouf Sinaba, Sidi M Niambele, Makonon Diallo, Seydina O Maguiraga, Sekouba Keita, Siaka Samake, Ahamadou Youssouf, Halimatou Diawara, Sekou F Traore, Roly Gosling, Joelle M Brown, Chris Drakeley, Alassane Dicko, Will Stone and Teun Bousema

The potential impact of declining development assistance for health on population health in Malawi: A modelling study pp. 1-14

Margherita Molaro, Paul Revill, Martin Chalkley, Sakshi Mohan, Tara D Mangal, Tim Colbourn, Joseph H Collins, Matthew M Graham, William Graham, Eva Janoušková, Gerald Manthalu, Emmanuel Mnjowe, Watipaso Mulwafu, Rachel E Murray-Watson, Pakwanja D Twea, Andrew N Phillips, Bingling She, Asif U Tamuri, Dominic Nkhoma, Joseph Mfutso-Bengo and Timothy B Hallett

Volume 22, issue 7, 2025

Inpatient psychiatric bed capacity within CMS-certified U.S hospitals, 2011–2023: A cross-sectional study pp. 1-15

Zoe Lindenfeld, Jonathan H Cantor, Colleen M McCullough, Jemar R Bather and Ryan K McBain

Charting the future of PLOS Medicine: Priorities for evidence, impact, and equity pp. 1-3

Helen Lumbard and Till Baernighausen

Progress and inequality in child immunization in 38 African countries, 2000–2030: A spatio-temporal Bayesian analysis at national and sub-national levels pp. 1-21

Phuong The Nguyen, Ryota Nakamura, Hideyasu Shimadzu, Aminu Kende Abubakar, Phuong Mai Le, Huy Van Nguyen, Hoa L Nguyen, Motohiro Sato, Ayako Honda and Stuart Gilmour

Passive immunotherapy for adults hospitalized with COVID-19: An individual participant data meta-analysis of six randomized controlled trials pp. 1-18

Kirk U Knowlton, Lianne K Siegel, Christina E Barkauskas, Sanjay Bhagani, Nila J Dharan, Edward M Gardner, Robert L Gottlieb, Marie Helleberg, Helene C Highbarger, Thomas L Holland, Christian Kjer Heerfordt, Susana Lazarte, Lindsey M Leither, Joseph Lutaakome, Magdalena Ardelt, Eleftherios Mylonakis, Sean W X Ong, J Scott Overcash, Hassan Taha, Phyllis C Tien, Barbara W Trautner, David Vallee, Amy C Weintrob, Giota Touloumi, Abdel Babiker and for the STRIVE ACTIV-3/TICO Study Group

Effect of a pay-it-forward strategy on reducing HPV vaccine delay and increasing uptake among 15- to 18-year-old girls in China: A randomized controlled trial pp. 1-14

Jing Li, Yifan Li, Chuanyu Qin, Yu He, Haidong Lu, Yewei Xie, Jason J Ong, Yajiao Lu, Ying Yang, Fan Yang, Heng Du, Wenfeng Gong, Fei Zou, Heidi J Larson, Mark Jit, Leesa Lin, Jennifer S Smith, Elvin H Geng, Dong Xu, Weiming Tang, Shenglan Tang, Joseph D Tucker and Dan Wu

Volume 22, issue 6, 2025

Vaccination strategies, public health impact and cost-effectiveness of dengue vaccine TAK-003: A modeling case study in Thailand pp. 1-26

Jing Shen, Elizaveta Kharitonova, Anna Tytula, Justyna Zawieja, Samuel Aballea, Shibadas Biswal, Mayuri Sharma, Supattra Rungmaitree, Rosarin Sruamsiri, Derek Wallace and Riona Hanley

Association of initiating CYP2D6-metabolized opioids with risks of adverse outcomes in older adults receiving antidepressants: A retrospective cohort study pp. 1-18

Yu-Jung Jenny Wei, Almut G Winterstein, Siegfried Schmidt, Roger B Fillingim, Michael J Daniels, Steven T DeKosky and Stephan Schmidt

The potential global health impact and cost-effectiveness of next-generation influenza vaccines: A modelling analysis pp. 1-17

Lucy Goodfellow, Simon R Procter, Mihaly Koltai, Naomi R Waterlow, Johnny A N Filipe, Carlos K H Wong, Edwin van Leeuwen, Rosalind M Eggo, Mark Jit, for the WHO Technical Advisory Group for the Full Value of Influenza Vaccines Assessment and project team and Next-generation influenza vaccine impact modelling Contributors

Volume 22, issue 5, 2025

Cost-effectiveness of screening with transcriptional signatures for incipient TB among U.S. migrants pp. 1-15

Yuli Lily Hsieh, C Robert Horsburgh, Ted Cohen, Jeffrey W Miller, Joshua A Salomon and Nicolas A Menzies

Alcohol intake and pancreatic cancer risk: An analysis from 30 prospective studies across Asia, Australia, Europe, and North America pp. 1-25

Sabine Naudin, Molin Wang, Niki Dimou, Elmira Ebrahimi, Jeanine Genkinger, Hans-Olov Adami, Demetrius Albanes, Ana Babic, Matt Barnett, David Bogumil, Hui Cai, Chu Chen, A Heather Eliassen, Jo L Freudenheim, Gretchen Gierach, Edward L Giovannucci, Marc J Gunter, Niclas Håkansson, Mayo Hirabayashi, Tao Hou, Brian Z Huang, Wen-Yi Huang, Harindra Jayasekara, Michael E Jones, Verena A Katzke, Woon-Puay Koh, James V Lacey, Ylva Trolle Lagerros, Susanna C Larsson, Linda M Liao, Kenneth Lo, Erikka Loftfield, Robert J MacInnis, Satu Männistö, Marjorie L McCullough, Anthony Miller, Roger L Milne, Steven C Moore, Lorelei A Mucci, Marian L Neuhouser, Alpa V Patel, Elizabeth A Platz, Anna Prizment, Kim Robien, Thomas E Rohan, Carlotta Sacerdote, Sven Sandin, Norie Sawada, Minouk Schoemaker, Xiao-Ou Shu, Rashmi Sinha, Linda Snetselaar, Meir J Stampfer, Rachael Stolzenberg-Solomon, Cynthia A Thomson, Anne Tjønneland, Caroline Y Um, Piet A van den Brandt, Kala Visvanathan, Sophia S Wang, Renwei Wang, Elisabete Weiderpass, Stephanie J Weinstein, Emily White, Walter Willett, Alicja Woslk, Brian M Wolpin, Shiaw-Shyuan S Yaun, Chen Yuan, Jian-Min Yuan, Wei Zheng, Paul Brennan, Stephanie A Smith-Warner and Pietro Ferrari

Volume 22, issue 4, 2025

Improving transparency in clinical trial reporting pp. 1-3

Alison Farrell and On Behalf of the PLOS Medicine Editors

A deep-learning algorithm using real-time collected intraoperative vital sign signals for predicting acute kidney injury after major non-cardiac surgeries: A modelling study pp. 1-16

Sehoon Park, Soomin Chung, Yisak Kim, Sun-Ah Yang, Soie Kwon, Jeong Min Cho, Min Jae Lee, Eunbyeol Cho, Jiwon Ryu, Sejoong Kim, Jeonghwan Lee, Hyung Jin Yoon, Edward Choi, Kwangsoo Kim and Hajeong Lee

Frailty in randomized controlled trials of glucose-lowering therapies for type 2 diabetes: An individual participant data meta-analysis of frailty prevalence, treatment efficacy, and adverse events pp. 1-15

Heather Wightman, Elaine Butterly, Lili Wei, Ryan McChrystal, Naveed Sattar, Amanda Adler, David Phillippo, Sofia Dias, Nicky Welton, Andrew Clegg, Miles Witham, Kenneth Rockwood, David A McAllister and Peter Hanlon

CONSORT 2025 statement: Updated guideline for reporting randomised trials pp. 1-15

Sally Hopewell, An-Wen Chan, Gary S Collins, Asbjørn Hróbjartsson, David Moher, Kenneth F Schulz, Ruth Tunn, Rakesh Aggarwal, Michael Berkwits, Jesse A Berlin, Nita Bhandari, Nancy J Butcher, Marion K Campbell, Runcie C W Chidebe, Diana Elbourne, Andrew Farmer, Dean A Fergusson, Robert M Golub, Steven N Goodman, Tammy C Hoffmann, John P A Ioannidis, Brennan C Kahan, Rachel L Knowles, Sarah E Lamb, Steff Lewis, Elizabeth Loder, Martin Offringa, Philippe Ravaud, Dawn P Richards, Frank W Rockhold, David L Schriger, Nandi L Siegried, Sophie Staniszewska, Rod S Taylor, Lehana Thabane, David Torgerson, Sunita Vohra, Ian R White and Isabelle Boutron

SPIRIT 2025 statement: Updated guideline for protocols of randomised trials pp. 1-15

An-Wen Chan, Isabelle Boutron, Sally Hopewell, David Moher, Kenneth F Schulz, Gary S Collins, Ruth Tunn, Rakesh Aggarwal, Michael Berkwits, Jesse A Berlin, Nita Bhandari, Nancy J Butcher, Marion K Campbell, Runcie C W Chidebe, Diana R Elbourne, Andrew J Farmer, Dean A Fergusson, Robert M Golub, Steven N Goodman, Tammy C Hoffmann, John P A Ioannidis, Brennan C Kahan, Rachel L Knowles, Sarah E Lamb, Steff Lewis, Elizabeth Loder, Martin Offringa, Philippe Ravaud, Dawn P Richards, Frank W Rockhold, David L Schriger, Nandi L Siegfried, Sophie Staniszewska, Rod S Taylor, Lehana Thabane, David J Torgerson, Sunita Vohra, Ian R White and Asbjørn Hróbjartsson

Reduced insulin use and diabetes complications upon introduction of SGLT-2 inhibitors and GLP1-receptor agonists in low- and middle-income countries: A microsimulation pp. 1-17

Global Health & Population Project on Access to Care for Cardiometabolic Diseases (HPACC)

Recurrence prediction using circulating tumor DNA in patients with early-stage non-small cell lung cancer after treatment with curative intent: A retrospective validation study pp. 1-23

Milou M F Schuurbiers, Christopher G Smith, Koen J Hartemink, Robert C Rintoul, Davina Gale, Kim Monkhorst, Bas L R Mandos, Anna L Paterson, Daan van den Broek, Nitzan Rosenfeld, Michel M van den Heuvel and On Behalf of the LEMA Study Group and the LUCID Study Group

Endovascular thrombectomy in acute stroke with a large ischemic core: A systematic review and meta-analysis of randomized controlled trials pp. 1-20

Chun-Hsien Lin, Meng Lee, Bruce Ovbiagele, David S Liebeskind, Borja Sanz-Cuesta and Jeffrey L Saver

Volume 22, issue 3, 2025

Direct and indirect impacts of the COVID-19 pandemic on life expectancy and person-years of life lost with and without disability: A systematic analysis for 18 European countries, 2020–2022 pp. 1-26

Sara Ahmadi-Abhari, Piotr Bandosz, Martin J Shipley, Joni V Lindbohm, Abbas Dehghan, Paul Elliott and Mika Kivimaki

Efficacy and safety of passive immunotherapies targeting amyloid beta in Alzheimer’s disease: A systematic review and meta-analysis pp. 1-29

Reina Tonegawa-Kuji, Yuan Hou, Bo Hu, Noah Lorincz-Comi, Andrew A Pieper, Babak Tousi, James B Leverenz and Feixiong Cheng

Risk factor analysis and creation of an externally-validated prediction model for perioperative stroke following non-cardiac surgery: A multi-center retrospective and modeling study pp. 1-16

Yulong Ma, Siyuan Liu, Faqiang Zhang, Xuhui Cong, Bingcheng Zhao, Miao Sun, Huikai Yang, Min Liu, Peng Li, Yuxiang Song, Jiangbei Cao, Yingfu Li, Wei Zhang, Kexuan Liu, Jiaqiang Zhang and Weidong Mi

Volume 22, issue 2, 2025

A systematic review of machine learning-based prognostic models for acute pancreatitis: Towards improving methods and reporting quality pp. 1-19

Brian Critelli, Amier Hassan, Ila Lahooti, Lydia Noh, Jun Sung Park, Kathleen Tong, Ali Lahooti, Nathan Matzko, Jan Niklas Adams, Lukas Liss, Justin Quion, David Restrepo, Melica Nikahd, Stacey Culp, Adam Lacy-Hulbert, Cate Speake, James Buxbaum, Jason Bischof, Cemal Yazici, Anna Evans-Phillips, Sophie Terp, Alexandra Weissman, Darwin Conwell, Philip Hart, Mitchell Ramsey, Somashekar Krishna, Samuel Han, Erica Park, Raj Shah, Venkata Akshintala, John A Windsor, Nikhil K Mull, Georgios Papachristou, Leo Anthony Celi and Peter Lee

The effect of prenatal balanced energy and protein supplementation on gestational weight gain: An individual participant data meta-analysis in low- and middle-income countries pp. 1-28

Dongqing Wang, Uttara Partap, Enju Liu, Janaína Calu Costa, Ilana R Cliffer, Molin Wang, Sudeer Kumar Nookala, Vishak Subramoney, Brittany Briggs, Imran Ahmed, Alemayehu Argaw, Shabina Ariff, Nita Bhandari, Ranadip Chowdhury, Daniel Erchick, Armando García-Guerra, Masoumah Ghaffarpour, Giles Hanley-Cook, Lieven Huybregts, Fyezah Jehan, Fatemeh Kaseb, Nancy F Krebs, Carl Lachat, Tsering Pema Lama, Dharma S Manandhar, Elizabeth M McClure, Sophie E Moore, Ameer Muhammad, Lynnette M Neufeld, Andrew M Prentice, Amado D Quezada-Sánchez, Dominique Roberfroid, Naomi M Saville, Yasir Shafiq, Bhim P Shrestha, Bakary Sonko, Sajid Soofi, Sunita Taneja, James M Tielsch, Laéticia Céline Toe, Naser Valaei and Wafaie W Fawzi

Consecutive prediction of adverse maternal outcomes of preeclampsia, using the PIERS-ML and fullPIERS models: A multicountry prospective observational study pp. 1-18

Guiyou Yang, Tünde Montgomery-Csobán, Wessel Ganzevoort, Sanne J Gordijn, Kimberley Kavanagh, Paul Murray, Laura A Magee, Henk Groen and Peter von Dadelszen

Accuracy and clinical effectiveness of risk prediction tools for pressure injury occurrence: An umbrella review pp. 1-29

Bethany Hillier, Katie Scandrett, April Coombe, Tina Hernandez-Boussard, Ewout Steyerberg, Yemisi Takwoingi, Vladica M Veličković and Jacqueline Dinnes

Predicting patent challenges for small-molecule drugs: A cross-sectional study pp. 1-15

Ally Memedovich, Brian Steele, Taylor Orr, Shanzeh Chaudhry, Mina Tadrous, Aaron S Kesselheim, Aidan Hollis and Reed F Beall

Improving monitoring of sexual, reproductive health, and rights globally pp. 1-3

Sacha St-Onge Ahmad and Zulfiqar A Bhutta

Volume 22, issue 1, 2025

Cost-effectiveness of leveraging existing HIV primary health systems and community health workers for hypertension screening and treatment in Africa: An individual-based modeling study pp. 1-25

Matthew D Hickey, James Ayieko, Jane Kabami, Asiphas Owaraganise, Elijah Kakande, Sabina Ogachi, Colette I Aoko, Erick M Wafula, Norton Sang, Helen Sunday, Paul Revill, Loveleen Bansi-Matharu, Starley B Shade, Gabriel Chamie, Laura B Balzer, Maya L Petersen, Diane V Havlir, Moses R Kamya and Andrew N Phillips

Factors associated with tuberculosis treatment initiation among bacteriologically negative individuals evaluated for tuberculosis: An individual patient data meta-analysis pp. 1-18

Sun Kim, Melike Hazal Can, Tefera B Agizew, Andrew F Auld, Maria Elvira Balcells, Stephanie Bjerrum, Keertan Dheda, Susan E Dorman, Aliasgar Esmail, Katherine Fielding, Alberto L Garcia-Basteiro, Colleen F Hanrahan, Wakjira Kebede, Mikashmi Kohli, Anne F Luetkemeyer, Carol Mita, Byron W P Reeve, Denise Rossato Silva, Sedona Sweeney, Grant Theron, Anete Trajman, Anna Vassall, Joshua L Warren, Marcel Yotebieng, Ted Cohen and Nicolas A Menzies

Psychological distress in adolescence and later economic and health outcomes in the United States population: A retrospective and modeling study pp. 1-23

Nathaniel Z Counts, Noemi Kreif, Timothy B Creedon and David E Bloom

Estimating the impact of school closures on the COVID-19 dynamics in 74 countries: A modelling analysis pp. 1-17

Romain Ragonnet, Angus E Hughes, David S Shipman, Michael T Meehan, Alec S Henderson, Guillaume Briffoteaux, Nouredine Melab, Daniel Tuyttens, Emma S McBryde and James M Trauer