Glycemic Control and the Risk of Tuberculosis: A Cohort Study

Pin-Hui Lee, Han Fu, Ting-Chun Lai, Chen-Yuan Chiang, Chang-Chuan Chan and Hsien-Ho Lin

PLOS Medicine, 2016, vol. 13, issue 8, 1-15

Abstract: Background: Diabetes is a well-known risk factor for tuberculosis (TB) and is increasingly prevalent in low- and middle-income countries, where the burden of TB is high. Glycemic control has the potential to modify the risk of TB. However, there are few studies on the association between glycemic control and TB risk, and the results are inconsistent. Methods and Findings: We assembled a cohort using 123,546 individuals who participated in a community-based health screening service in northern Taiwan from 5 March 2005 to 27 July 2008. Glycemic control was measured using fasting plasma glucose (FPG) at the time of screening. The cohort was followed up to 31 December 2012 for the occurrence of TB by cross-matching the screening database to the national health insurance database. Multiple imputation was used to handle missing information. During a median follow-up of 4.6 y, 327 cases of TB occurred. In the multivariable Cox regression model, diabetic patients with poor glycemic control (FPG > 130 mg/dl) had a significantly higher hazard of TB (adjusted hazard ratio [aHR] 2.21, 95% CI 1.63–2.99, p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pmed00:1002072

DOI: 10.1371/journal.pmed.1002072

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