International gestational age-specific centiles for blood pressure in pregnancy from the INTERGROWTH-21st Project in 8 countries: A longitudinal cohort study

Lauren J Green, Stephen H Kennedy, Lucy Mackillop, Stephen Gerry, Manorama Purwar, Eleonora Staines Urias, Leila Cheikh Ismail, Fernando Barros, Cesar Victora, Maria Carvalho, Eric Ohuma, Yasmin Jaffer, J Alison Noble, Michael Gravett, Ruyan Pang, Ann Lambert, Enrico Bertino, Aris T Papageorghiou, Cutberto Garza, Zulfiqar Bhutta, José Villar, Peter Watkinson and for the International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st)

PLOS Medicine, 2021, vol. 18, issue 4, 1-16

Abstract: Background: Gestational hypertensive and acute hypotensive disorders are associated with maternal morbidity and mortality worldwide. However, physiological blood pressure changes in pregnancy are insufficiently defined. We describe blood pressure changes across healthy pregnancies from the International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st) Fetal Growth Longitudinal Study (FGLS) to produce international, gestational age-specific, smoothed centiles (third, 10th, 50th, 90th, and 97th) for blood pressure. Methods and findings: Secondary analysis of a prospective, longitudinal, observational cohort study (2009 to 2016) was conducted across 8 diverse urban areas in Brazil, China, India, Italy, Kenya, Oman, the United Kingdom, and the United States of America. We enrolled healthy women at low risk of pregnancy complications. We measured blood pressure using standardised methodology and validated equipment at enrolment at

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pmed00:1003611

DOI: 10.1371/journal.pmed.1003611

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