Screening uptake of colonoscopy versus fecal immunochemical testing in first-degree relatives of patients with non-syndromic colorectal cancer: A multicenter, open-label, parallel-group, randomized trial (ParCoFit study)

Natalia González-López, Enrique Quintero, Antonio Z Gimeno-Garcia, Luis Bujanda, Jesús Banales, Joaquin Cubiella, María Salve-Bouzo, Jesus Miguel Herrero-Rivas, Estela Cid-Delgado, Victoria Alvarez-Sanchez, Alejandro Ledo-Rodríguez, Maria Luisa de-Castro-Parga, Romina Fernández-Poceiro, Luciano Sanromán-Álvarez, Jose Santiago-Garcia, Alberto Herreros- de-Tejada, Teresa Ocaña-Bombardo, Francesc Balaguer, María Rodríguez-Soler, Rodrigo Jover, Marta Ponce, Cristina Alvarez-Urturi, Xavier Bessa, Maria-Pilar Roncales, Federico Sopeña, Angel Lanas, David Nicolás-Pérez, Zaida Adrián- de-Ganzo, Marta Carrillo-Palau, Enrique González-Dávila and On behalf of the Oncology Group of Asociación Española de Gastroenterología

PLOS Medicine, 2023, vol. 20, issue 10, 1-21

Abstract: Background: Colonoscopy screening is underused by first-degree relatives (FDRs) of patients with non-syndromic colorectal cancer (CRC) with screening completion rates below 50%. Studies conducted in FDR referred for screening suggest that fecal immunochemical testing (FIT) was not inferior to colonoscopy in terms of diagnostic yield and tumor staging, but screening uptake of FIT has not yet been tested in this population. In this study, we investigated whether the uptake of FIT screening is superior to the uptake of colonoscopy screening in the familial-risk population, with an equivalent effect on CRC detection. Methods and findings: This open-label, parallel-group, randomized trial was conducted in 12 Spanish centers between February 2016 and December 2021. Eligible individuals included asymptomatic FDR of index cases

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pmed00:1004298

DOI: 10.1371/journal.pmed.1004298

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