Deep brain stimulation surgical timing, outcomes, and prognostic factors in patients with Parkinson’s disease: A Chinese retrospective multicenter cohort study

Shu Wang, Wei Hu, Yuan Gao, Anxin Wang, Ling Chen, Zhanhua Liang, Shizhong Zhang, Hao Long, Weiguo Li, Chaoshi Niu, Weiguo Liu, Guoen Cai, Yuchen Ji, Joseph Tam, Qin Xu, Anchao Yang, Lin Shi, Hua Zhang, Chunlei Han, Guanyu Zhu, Yutong Bai, Lulu Jiang, Tao Li, Shan Xue, Hongxiao Wang, Yuexuan Li, Chi Xiong, Andres M Lozano, Adolfo Ramirez-Zamora, Wenbin Zhang, Fangang Meng, Jianguo Zhang and Collaboration Dbs-Pdcc2

PLOS Medicine, 2025, vol. 22, issue 8, 1-25

Abstract: Background: Deep brain stimulation (DBS) has been increasingly introduced for patients with Parkinson’s disease (PD). However, there has been extensive controversy regarding its surgical timing. This study aimed to evaluate surgical outcomes of DBS across different PD durations and identify key prognostic factors. Methods and findings: In this multicenter cohort study, patients with PD who underwent subthalamic DBS between 1/1/2011 and 12/31/2020 from seven representative Chinese national centers were included. Two-year follow-up data were analyzed, accordingly. These patients were classified into short (

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pmed00:1004670

DOI: 10.1371/journal.pmed.1004670

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