The data transparency crisis in research: Lessons from systematic reviews and meta-analyses

Saul Martin-Rodriguez, Rodrigo Fernandez-Gonzalo and David Moher

PLOS Medicine, 2026, vol. 23, issue 6, 1-7

Abstract: Summary points: Systematic reviews and meta-analyses underpin clinical guidelines and health policy, yet their validity may be compromised by limited access to underlying datasets and associated analytical code.Reliance on incomplete or inconsistently reported summary statistics forces researchers to use imputation and unverifiable assumptions, which can distort effect estimates and mislead clinical decision-making.The consequences extend beyond methodology: flawed evidence synthesis can influence treatment recommendations, healthcare spending, and patient safety, as illustrated by historical cases such as hormone replacement therapy.Despite widespread data-sharing policies, compliance remains low, enforcement weak, and monitoring almost non-existent, with many datasets remaining unavailable or inaccessible.This Policy Forum argues for strengthening enforceable data-sharing mechanisms, including clearer enforcement and pragmatic verification approaches within editorial workflows. Systematic reviews and meta-analyses underpin clinical guidelines and health policy, yet their validity may be compromised by limited access to underlying datasets and associated analytical code. This Policy Forum by Saul Martin-Rodriguez and colleagues argues for strengthening enforceable data-sharing mechanisms, including clearer enforcement and pragmatic verification approaches within editorial workflows.

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pmed00:1005145

DOI: 10.1371/journal.pmed.1005145

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