Association between nirsevimab coverage and pediatric emergency department visits for bronchiolitis in 12 European countries: An interrupted time-series analysis

Lenglart, Léa; Titomanlio, Luigi; Alberti, Ilaria; Almeida, Laura; Aupiais, Camille; Özkan, Esra Akyüz; Barrett, Michael; Basmaci, Romain; Birbilen, Ahmet; Borensztajn, Dorine; Schönenberger, Catarina Braz; Bressan, Silvia; Buonsenso, Danilo; Campos, Teresa; Castanhinha, Susana; Chiaretti, Antonio; Claret, Gemma; De Zan, Francesca; Durnin, Sheena; Fodor, Laszlo; Gomez, Borja; Greber-Platzer, Susanne; Guedj, Romain; Huege, Alexander; Leonard, Fiona; Maconochie, Ian K; Marlow, Robin; Milani, Gregorio; Gutierrez, Miguel Angel Molina; Musolino, Anna Maria; Oostenbrink, Rianne; Pucuka, Zanda; Rivière, Simon; Roland, Damian; Rinder, Malin Ryd; Supino, Maria Chiara; Teksam, Ozlem; Trenchs, Victoria; Liebert, Zaba Valtuille; Vanda, Bento; Vrijlandt, Sanne; Ouldali, Naim; Nijman, Ruud G; Group, the EPISODES Study

Association between nirsevimab coverage and pediatric emergency department visits for bronchiolitis in 12 European countries: An interrupted time-series analysis

Léa Lenglart, Luigi Titomanlio, Ilaria Alberti, Laura Almeida, Camille Aupiais, Esra Akyüz Özkan, Michael Barrett, Romain Basmaci, Ahmet Birbilen, Dorine Borensztajn, Catarina Braz Schönenberger, Silvia Bressan, Danilo Buonsenso, Teresa Campos, Susana Castanhinha, Antonio Chiaretti, Gemma Claret, Francesca De Zan, Sheena Durnin, Laszlo Fodor, Borja Gomez, Susanne Greber-Platzer, Romain Guedj, Alexander Huege, Fiona Leonard, Ian K Maconochie, Robin Marlow, Gregorio Milani, Miguel Angel Molina Gutierrez, Anna Maria Musolino, Rianne Oostenbrink, Zanda Pucuka, Simon Rivière, Damian Roland, Malin Ryd Rinder, Maria Chiara Supino, Ozlem Teksam, Victoria Trenchs, Zaba Valtuille Liebert, Bento Vanda, Sanne Vrijlandt, Naim Ouldali, Ruud G Nijman and the EPISODES Study Group

PLOS Medicine, 2026, vol. 23, issue 9, 1-17

Abstract: Background: Nirsevimab was introduced to prevent Respiratory Syncytial Virus (RSV) bronchiolitis in infants. Despite its proven effectiveness and similar guidelines across Europe, bronchiolitis reduction varied across Europe. This study explored whether nirsevimab coverage among targeted populations (born in- and out-of-season) was associated to this variability. Methods and findings: We used routinely collected data from 27 pediatric emergency departments across 12 European countries (01/2018–03/2024). All bronchiolitis cases aged

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pmed00:1005223

DOI: 10.1371/journal.pmed.1005223

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