Addressing threats to validity in large dataset research

Wonsuk Yoo and John P A Ioannidis

PLOS Medicine, 2026, vol. 23, issue 11, 1-18

Abstract: In this Guidelines and Guidance article, Wonsuk Yoo and John P.A. Ioannidis outline why research using large datasets faces threats to validity, highlighting four main statistical pitfalls and providing guidance and worked examples on how to mitigate against them.

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pmed00:1005282

DOI: 10.1371/journal.pmed.1005282

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