Unusual Dengue Virus 3 Epidemic in Nicaragua, 2009

Gamaliel Gutierrez, Katherine Standish, Federico Narvaez, Maria Angeles Perez, Saira Saborio, Douglas Elizondo, Oscar Ortega, Andrea Nuñez, Guillermina Kuan, Angel Balmaseda and Eva Harris

PLOS Neglected Tropical Diseases, 2011, vol. 5, issue 11, 1-13

Abstract: The four dengue virus serotypes (DENV1–4) cause the most prevalent mosquito-borne viral disease affecting humans worldwide. In 2009, Nicaragua experienced the largest dengue epidemic in over a decade, marked by unusual clinical presentation, as observed in two prospective studies of pediatric dengue in Managua. From August 2009–January 2010, 212 dengue cases were confirmed among 396 study participants at the National Pediatric Reference Hospital. In our parallel community-based cohort study, 170 dengue cases were recorded in 2009–10, compared to 13–65 cases in 2004–9. In both studies, significantly more patients experienced “compensated shock” (poor capillary refill plus cold extremities, tachycardia, tachypnea, and/or weak pulse) in 2009–10 than in previous years (42.5% [90/212] vs. 24.7% [82/332] in the hospital study (p

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0001394

DOI: 10.1371/journal.pntd.0001394

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