Cost-effectiveness of vector control for supplementing mass drug administration for eliminating lymphatic filariasis in India

Donald S Shepard, Aung K Lwin, Sunish I Pulikkottil, Mariapillai Kalimuthu, Natarajan Arunachalam, Brij K Tyagi and Graham B White

PLOS Neglected Tropical Diseases, 2024, vol. 18, issue 12, 1-24

Abstract: Background/Methodology: Despite progress using mass drug administration (MDA), lymphatic filariasis (LF) remains a major public health issue in India. Vector control could potentially augment MDA towards LF elimination. We conducted a cost-effectiveness analysis of MDA alone and MDA together with vector control single (VCS) modality or vector control integrated (VCI) modalities. Data came from historical controls and a three-arm cluster randomized trial of 36 villages at risk of LF transmission in Tamil Nadu, India. The arms were: MDA alone (the standard of care); MDA plus VCS (expanded polystyrene beads covering the water surface in wells and cesspits to suppress the filariasis vector mosquito Culex quinquefasciatus); and MDA plus VCI (VCS plus insecticidal pyrethroid-impregnated curtains [over windows, doors, and eaves). Economic costs in 2010 US$ combined government and community inputs from household to state levels. Outcomes were controlled microfilaria prevalence (MfP) and antigen prevalence (AgP) to conventional elimination targets (MfP

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0011835

DOI: 10.1371/journal.pntd.0011835

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