Prevention of congenital chagas disease by trypanocide treatment in women of reproductive age: A meta-analysis of observational studies

Francisco Cezar Aquino de Moraes, Maria Eduarda Cavalcanti Souza, Lucca Dal Moro, Isabelle Batista Donadon, Emanuele Rocha da Silva, Dilma do Socorro Moraes de Souza and Rommel Mario Rodríguez Burbano

PLOS Neglected Tropical Diseases, 2024, vol. 18, issue 9, 1-13

Abstract: Background: Maternal-foetal transmission of Chagas disease (CD) affects newborns worldwide. Although Benznidazole and Nifurtimox therapies are the standard treatments, their use during pregnancy is contra-indicated. The effectiveness of trypanocidal medications in preventing congenital Chagas Disease (cCD) in the offsprings of women diagnosed with CD was highly suggested by other studies. Methods: We performed a systematic review and meta-analysis of studies evaluating the effectiveness of treatment for CD in women of childbearing age and reporting frequencies of cCD in their children. PubMed, Scopus, Web of Science, Cochrane Library, and LILACS databases were systematically searched. Statistical analysis was performed using Rstudio 4.2 using DerSimonian and Laird random-effects models. Heterogeneity was examined with the Cochran Q test and I2 statistics. A p-value of

Date: 2024
References: Add references at CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0012407 (text/html)
https://journals.plos.org/plosntds/article/file?id ... 12407&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0012407

DOI: 10.1371/journal.pntd.0012407

Access Statistics for this article

More articles in PLOS Neglected Tropical Diseases from Public Library of Science
Bibliographic data for series maintained by plosntds ().