Development and validation of a simple-to-use nomogram for predicting severe scrub typhus in children

Yonghan Luo, Yan Guo, Yanchun Wang and Xiaotao Yang

PLOS Neglected Tropical Diseases, 2025, vol. 19, issue 5, 1-15

Abstract: Objective: This study aimed to develop and validate a simple-to-use nomogram for predicting severe scrub typhus (ST) in children. Methods: A retrospective study of 256 patients with ST was performed at the Kunming Children’s Hospital from January 2015 to November 2022. ALL patients were divided into a common and severe group based on the severity of the disease. A least absolute shrinkage and selection operator (LASSO) regression model was used to identify the optimal predictors, and the predictive nomogram was plotted by multivariable logistic regression. The nomogram was assessed by calibration, discrimination, and clinical utility. Results: LASSO regression analysis identified that hemoglobin count (Hb), platelet count (PLT), lactate dehydrogenase (LDH), blood urea nitrogen (BUN), creatine kinase isoenzyme MB(CK-MB) and hypoproteinemia were the optimal predictors for severe ST. The nomogram was plotted by the six predictors. The area under the receiver operating characteristic (ROC) curve of the nomogram was 0.870(95% CI = 0.812 ~ 0.928) in training set and 0.839(95% CI = 0.712 ~ 0.967) in validation set. The calibration curve demonstrated that the nomogram was well-fitted, and the decision curve analysis (DCA) showed that the nomogram was clinically beneficial. Conclusions: This study developed and validated a simple‐to‐use nomogram for predicting severe ST in children based on six predictors including Hb, PLT, LDH, BUN, CK-MB and hypoproteinemia, demonstrating excellent predictive accuracy for the data, though external and prospective validation is required to assess its potential clinical utility. Author summary: Scrub typhus (ST) is a serious infectious disease caused by Orientia tsutsugamushi transmitted through mite bites. It is particularly dangerous for children, and predicting its severity is critical for timely intervention. This study aimed to develop a simple, user-friendly tool to predict severe ST in children. Through a retrospective analysis of clinical data from 256 ST patients, we identified six critical factors—hemoglobin count (Hb), platelet count (PLT), lactate dehydrogenase (LDH), blood urea nitrogen (BUN), creatine kinase isoenzyme MB(CK-MB) and hypoproteinemia—that can predict disease severity. Based on these six factors, we developed a nomogram tool to assist healthcare providers in quickly assessing the risk of severe ST in children. The validation of the nomogram demonstrated its accuracy and utility in clinical decision-making. Our findings suggest that this nomogram could serve as a valuable tool in pediatric healthcare, aiding physicians in identifying children at higher risk for severe ST and making more informed treatment decisions.

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0013090

DOI: 10.1371/journal.pntd.0013090

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