The Influence of Clinical Information in the Histopathologic Diagnosis of Melanocytic Skin Neoplasms

Gerardo Ferrara, Zsolt Argenyi, Giuseppe Argenziano, Rino Cerio, Lorenzo Cerroni, Arturo Di Blasi, Elisa A A Feudale, Caterina M Giorgio, Cesare Massone, Oscar Nappi, Carlo Tomasini, Carmelo Urso, Iris Zalaudek, Harald Kittler and H Peter Soyer

PLOS ONE, 2009, vol. 4, issue 4, 1-7

Abstract: Background: We tested the relevance of clinical information in the histopathologic evaluation of melanocytic skin neoplasm (MSN). Methods: Histopathologic specimens from 99 clinically atypical MSN were circulated among ten histopathologists; each case had clinical information available in a database with a five-step procedure (no information; age/sex/location; clinical diagnosis; clinical image; dermoscopic image); each step had a histopathologic diagnosis (D1 through D5); each diagnostic step had a level of diagnostic confidence (LDC) ranging from 1 (no diagnostic certainty) to 5 (absolute diagnostic certainty). The comparison of the LDC was employed with an analysis of variance (ANOVA) for repeated measures. Findings: In D1 (no information), 36/99 cases (36.3%) had unanimous diagnosis; in D5 (full information available), 51/99 cases (51.5%) had unanimous diagnosis (p for difference between proportions

Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0005375

DOI: 10.1371/journal.pone.0005375

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