The Oxytocin Receptor (OXTR) Contributes to Prosocial Fund Allocations in the Dictator Game and the Social Value Orientations Task

Salomon Israel, Elad Lerer, Idan Shalev, Florina Uzefovsky, Mathias Riebold, Efrat Laiba, Rachel Bachner-Melman, Anat Maril, Gary Bornstein, Ariel Knafo and Richard P Ebstein

PLOS ONE, 2009, vol. 4, issue 5, 1-10

Abstract: Background: Economic games observe social decision making in the laboratory that involves real money payoffs. Previously we have shown that allocation of funds in the Dictator Game (DG), a paradigm that illustrates costly altruistic behavior, is partially determined by promoter-region repeat region variants in the arginine vasopressin 1a receptor gene (AVPR1a). In the current investigation, the gene encoding the related oxytocin receptor (OXTR) was tested for association with the DG and a related paradigm, the Social Values Orientation (SVO) task. Methodology/Principal Findings: Association (101 male and 102 female students) using a robust-family based test between 15 single tagging SNPs (htSNPs) across the OXTR was demonstrated with both the DG and SVO. Three htSNPs across the gene region showed significant association with both of the two games. The most significant association was observed with rs1042778 (p = 0.001). Haplotype analysis also showed significant associations for both DG and SVO. Following permutation test adjustment, significance was observed for 2–5 locus haplotypes (p

Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0005535

DOI: 10.1371/journal.pone.0005535

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