Early Antiretroviral Therapy Reduces AIDS Progression/Death in Individuals with Acute Opportunistic Infections: A Multicenter Randomized Strategy Trial

Andrew R Zolopa, Janet Andersen, Lauren Komarow, Ian Sanne, Alejandro Sanchez, Evelyn Hogg, Carol Suckow, William Powderly and for the ACTG A5164 study Team

PLOS ONE, 2009, vol. 4, issue 5, 1-10

Abstract: Background: Optimal timing of ART initiation for individuals presenting with AIDS-related OIs has not been defined. Methods and Findings: A5164 was a randomized strategy trial of “early ART” - given within 14 days of starting acute OI treatment versus “deferred ART” - given after acute OI treatment is completed. Randomization was stratified by presenting OI and entry CD4 count. The primary week 48 endpoint was 3-level ordered categorical variable: 1. Death/AIDS progression; 2. No progression with incomplete viral suppression (ie HIV viral load (VL) ≥50 copies/ml); 3. No progression with optimal viral suppression (ie HIV VL

Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0005575

DOI: 10.1371/journal.pone.0005575

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