Longitudinal Study of CSF Biomarkers in Patients with Alzheimer's Disease

Peder Buchhave, Kaj Blennow, Henrik Zetterberg, Erik Stomrud, Elisabet Londos, Niels Andreasen, Lennart Minthon and Oskar Hansson

PLOS ONE, 2009, vol. 4, issue 7, 1-5

Abstract: Background: The CSF biomarkers tau and Aβ42 can identify patients with AD, even during the preclinical stages. However, previous studies on longitudinal changes of tau and Aβ42 in individual patients with AD and elderly controls report somewhat inconsistent results. Methodology/Principal Findings: We investigated the levels of tau and Aβ42 at baseline and after 1 year in 100 patients with AD. In a second cohort of 45 AD patients we measured the CSF biomarkers at baseline and after 2 years. Moreover, in 34 healthy elderly controls the CSF biomarkers were followed for 4 years. The baseline levels of tau were increased with >60% in AD patients compared to controls (p 50% (p

Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0006294

DOI: 10.1371/journal.pone.0006294

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