Comparison of Two Quantitative Methods of Discerning Airspace Enlargement in Smoke-Exposed Mice

Richard E Jacob, James P Carson, Kathy M Gideon, Brett G Amidan, Cathie L Smith and K Monica Lee

PLOS ONE, 2009, vol. 4, issue 8, 1-7

Abstract: In this work, we compare two methods for evaluating and quantifying pulmonary airspace enlargement in a mouse model of chronic cigarette smoke exposure. Standard stereological sample preparation, sectioning, and imaging of mouse lung tissues were performed for semi-automated acquisition of mean linear intercept (Lm) data. After completion of the Lm measurements, D2, a metric of airspace enlargement, was measured in a blinded manner on the same lung images using a fully automated technique developed in-house. An analysis of variance (ANOVA) shows that although Lm was able to separate the smoke-exposed and control groups with statistical significance (p = 0.034), D2 was better able to differentiate the groups (p

Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0006670

DOI: 10.1371/journal.pone.0006670

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