Models for Prediction of Factor VIII Half-Life in Severe Haemophiliacs: Distinct Approaches for Blood Group O and Non-O Patients

Kathelijn Fischer, Ronan Pendu, Carina J van Schooten, Karin van Dijk, Cécile V Denis, H Marijke van den Berg and Peter J Lenting

PLOS ONE, 2009, vol. 4, issue 8, 1-7

Abstract: Background: Von Willebrand factor (VWF) is critical for the in vivo survival of factor VIII (FVIII). Since FVIII half-life correlates with VWF-antigen pre-infusion levels, we hypothesized that VWF levels are useful to predict FVIII half-life. Methodology: Standardized half-life studies and analysis of pre-infusion VWF and VWF-propeptide levels were performed in a cohort of 38 patients with severe haemophilia A (FVIII

Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0006745

DOI: 10.1371/journal.pone.0006745

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