A Role for S1P and S1P1 in Immature-B Cell Egress from Mouse Bone Marrow

João Pedro Pereira, Jason G Cyster and Ying Xu

PLOS ONE, 2010, vol. 5, issue 2, 1-6

Abstract: B lymphocyte egress from secondary lymphoid organs requires sphingosine-1-phosphate (S1P) and S1P receptor-1 (S1P1). However, whether S1P contributes to immature-B cell egress from the bone marrow (BM) has not been fully assessed. Here we report that in S1P- and S1P1-conditionally deficient mice, the number of immature-B cells in the BM parenchyma increased, while it decreased in the blood. Moreover, a slower rate of bromodeoxyuridine incorporation suggested immature-B cells spent longer in the BM of mice in which S1P1-S1P signaling was genetically or pharmacologically impaired. Transgenic expression of S1P1 in developing B cells was sufficient to mobilize pro- and pre-B cells from the BM. We conclude that the S1P1-S1P pathway contributes to egress of immature-B cells from BM, and that this mechanism is partially redundant with other undefined pathways.

Date: 2010
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0009277

DOI: 10.1371/journal.pone.0009277

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