Statin Treatment and Mortality in Bacterial Infections – A Systematic Review and Meta-Analysis

Linda Björkhem-Bergman, Peter Bergman, Jan Andersson and Jonatan D Lindh

PLOS ONE, 2010, vol. 5, issue 5, 1-8

Abstract: Background: Several studies have reported improved survival in severe bacterial infections among statin treated patients. In addition, statins have been ascribed beneficial anti-inflammatory effects. The aim of this study was to evaluate the effect of statin-treatment on mortality in patients with bacterial infections, by means of a systematic review and a meta-analysis. Methodology and Principal Findings: Studies investigating the association between statin use and mortality in patients with bacterial disease were identified in a systematic literature review and a meta-analysis was performed to calculate the overall odds ratio of mortality in statin users. The literature search identified 947 citations from which 40 relevant studies were extracted. In all, 15 studies comprising 113 910 patients were included in the final analysis. Statin use was associated with a significantly (p

Date: 2010
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0010702

DOI: 10.1371/journal.pone.0010702

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