An Updated Meta-Analysis of Risk of Multiple Sclerosis following Infectious Mononucleosis

Adam E Handel, Alexander J Williamson, Giulio Disanto, Lahiru Handunnetthi, Gavin Giovannoni and Sreeram V Ramagopalan

PLOS ONE, 2010, vol. 5, issue 9, 1-5

Abstract: Background: Multiple sclerosis (MS) appears to develop in genetically susceptible individuals as a result of environmental exposures. Epstein-Barr virus (EBV) infection is an almost universal finding among individuals with MS. Symptomatic EBV infection as manifested by infectious mononucleosis (IM) has been shown in a previous meta-analysis to be associated with the risk of MS, however a number of much larger studies have since been published. Methods/Principal Findings: We performed a Medline search to identify articles published since the original meta-analysis investigating MS risk following IM. A total of 18 articles were included in this study, including 19390 MS patients and 16007 controls. We calculated the relative risk of MS following IM using a generic inverse variance with random effects model. This showed that the risk of MS was strongly associated with IM (relative risk (RR) 2.17; 95% confidence interval 1.97–2.39; p

Date: 2010
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0012496

DOI: 10.1371/journal.pone.0012496

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