Alpha-Adducin Gly460Trp Polymorphism and Hypertension Risk: A Meta-Analysis of 22 Studies Including 14303 Cases and 15961 Controls

Kuo Liu, Jielin Liu, Yan Huang, Ya Liu, Yuqing Lou, Zuoguang Wang, Hong Zhang, Shan Yan, Zhizhong Li and Shaojun Wen

PLOS ONE, 2010, vol. 5, issue 9, 1-9

Abstract: Background: No clear consensus has been reached on the alpha-adducin polymorphism (Gly460Trp) and essential hypertension risk. We performed a meta-analysis in an effort to systematically summarize the possible association. Methodology/Principal Findings: Studies were identified by searching MEDLINE and EMBASE databases complemented with perusal of bibliographies of retrieved articles and correspondence with original authors. The fixed-effects model and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. We selected 22 studies that met the inclusion criteria including a total of 14303 hypertensive patients and 15961 normotensive controls. Overall, the 460Trp allele showed no statistically significant association with hypertension risk compared to Gly460 allele (P = 0.69, OR = 1.02, 95% CI 0.94–1.10, Pheterogeneity

Date: 2010
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0013057

DOI: 10.1371/journal.pone.0013057

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