IL28B SNP rs8099917 Is Strongly Associated with Pegylated Interferon-α and Ribavirin Therapy Treatment Failure in HCV/HIV-1 Coinfected Patients

Ester Aparicio, Mariona Parera, Sandra Franco, Nuria Pérez-Alvarez, Cristina Tural, Bonaventura Clotet and Miguel Angel Martínez

PLOS ONE, 2010, vol. 5, issue 10, 1-5

Abstract: Recent genome-wide association studies report that the SNP rs8099917, located 8.9 kb upstream of the start codon of IL28B, is associated with both disease chronicity and therapeutic response to pegIFN-α and RBV in patients infected with genotype 1 HCV. To determine the effect of rs8099917 variation on the response of HCV to therapy, we genotyped this variant in a cohort of 160 HCV/HIV-1 coinfected patients in our clinic unit who received combined peg-IFN-α/RBV therapy. The rs8099917 T/G or G/G genotypes were observed in 56 patients (35%). Treatment failure occurred in 80% of G-allele carriers versus 48% of non-carriers (P

Date: 2010
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0013771

DOI: 10.1371/journal.pone.0013771

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