JULIDE: A Software Tool for 3D Reconstruction and Statistical Analysis of Autoradiographic Mouse Brain Sections

Delphine Ribes, Julia Parafita, Rémi Charrier, Fulvio Magara, Pierre J Magistretti and Jean-Philippe Thiran

PLOS ONE, 2010, vol. 5, issue 11, 1-8

Abstract: In this article we introduce JULIDE, a software toolkit developed to perform the 3D reconstruction, intensity normalization, volume standardization by 3D image registration and voxel-wise statistical analysis of autoradiographs of mouse brain sections. This software tool has been developed in the open-source ITK software framework and is freely available under a GPL license. The article presents the complete image processing chain from raw data acquisition to 3D statistical group analysis. Results of the group comparison in the context of a study on spatial learning are shown as an illustration of the data that can be obtained with this tool.

Date: 2010
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0014094

DOI: 10.1371/journal.pone.0014094

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