Mathematical Modeling for the Pathogenesis of Alzheimer's Disease

Ishwar K Puri and Liwu Li

PLOS ONE, 2010, vol. 5, issue 12, 1-5

Abstract: Despite extensive research, the pathogenesis of neurodegenerative Alzheimer's disease (AD) still eludes our comprehension. This is largely due to complex and dynamic cross-talks that occur among multiple cell types throughout the aging process. We present a mathematical model that helps define critical components of AD pathogenesis based on differential rate equations that represent the known cross-talks involving microglia, astroglia, neurons, and amyloid-β (Aβ). We demonstrate that the inflammatory activation of microglia serves as a key node for progressive neurodegeneration. Our analysis reveals that targeting microglia may hold potential promise in the prevention and treatment of AD.

Date: 2010
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0015176

DOI: 10.1371/journal.pone.0015176

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