Smoking and Multiple Sclerosis: An Updated Meta-Analysis

Adam E Handel, Alexander J Williamson, Giulio Disanto, Ruth Dobson, Gavin Giovannoni and Sreeram V Ramagopalan

PLOS ONE, 2011, vol. 6, issue 1, 1-6

Abstract: Background: Multiple sclerosis (MS) is a leading cause of disability in young adults. Susceptibility to MS is determined by environmental exposure on the background of genetic risk factors. A previous meta-analysis suggested that smoking was an important risk factor for MS but many other studies have been published since then. Methods/Principal Findings: We performed a Medline search to identify articles published that investigated MS risk following cigarette smoking. A total of 14 articles were included in this study. This represented data on 3,052 cases and 457,619 controls. We analysed these studies in both a conservative (limiting our analysis to only those where smoking behaviour was described prior to disease onset) and non-conservative manner. Our results show that smoking is associated with MS susceptibility (conservative: risk ratio (RR) 1.48, 95% confidence interval (CI) 1.35–1.63, p

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0016149

DOI: 10.1371/journal.pone.0016149

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