An Investigation of Genome-Wide Studies Reported Susceptibility Loci for Ulcerative Colitis Shows Limited Replication in North Indians

Garima Juyal, Pushplata Prasad, Sabyasachi Senapati, Vandana Midha, Ajit Sood, Devendra Amre, Ramesh C Juyal and Thelma Bk

PLOS ONE, 2011, vol. 6, issue 1, 1-6

Abstract: Genome-Wide Association studies (GWAS) of both Crohn's Disease (CD) and Ulcerative Colitis (UC) have unearthed over 40 risk conferring variants. Recently, a meta-analysis on UC revealed several loci, most of which were either previously associated with UC or CD susceptibility in populations of European origin. In this study, we attempted to replicate these findings in an ethnically distinct north Indian UC cohort. 648 UC cases and 850 controls were genotyped using Infinium Human 660W-quad. Out of 59 meta-analysis index SNPs, six were not in the SNP array used in the study. Of the remaining 53 SNPs, four were found monomorphic. Association (p

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0016565

DOI: 10.1371/journal.pone.0016565

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