Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach

Yvonne J K Edwards, Gary W Beecham, William K Scott, Sawsan Khuri, Guney Bademci, Demet Tekin, Eden R Martin, Zhijie Jiang, Deborah C Mash, Jarlath ffrench-Mullen, Margaret A Pericak-Vance, Nicholas Tsinoremas and Jeffery M Vance

PLOS ONE, 2011, vol. 6, issue 2, 1-11

Abstract: Parkinson's disease (PD) has had six genome-wide association studies (GWAS) conducted as well as several gene expression studies. However, only variants in MAPT and SNCA have been consistently replicated. To improve the utility of these approaches, we applied pathway analyses integrating both GWAS and gene expression. The top 5000 SNPs (p

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0016917

DOI: 10.1371/journal.pone.0016917

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