The Association of Mid-Regional Pro-Adrenomedullin and Mid-Regional Pro-Atrial Natriuretic Peptide with Mortality in an Incident Dialysis Cohort

Ghazaleh Gouya, Gisela Sturm, Claudia Lamina, Emanuel Zitt, Otto Freistätter, Joachim Struck, Michael Wolzt, Florian Knoll, Friederike Lins, Karl Lhotta, Ulrich Neyer and Florian Kronenberg

PLOS ONE, 2011, vol. 6, issue 3, 1-11

Abstract: High levels of the plasma peptides mid-regional pro-adrenomedullin (MR-proADM) and mid-regional pro-atrial natriuretic peptide (MR-proANP) are associated with clinical outcomes in the general population. Data in patients with chronic kidney disease are sparse. We therefore investigated the association of MR-proANP and MR-proADM levels with all-cause and cardiovascular (CV) mortality, CV events and peripheral arterial disease in 201 incident dialysis patients of the INVOR-Study prospectively followed for a period of up to more than 7 years. The overall mortality rate was 43%, thereof 43% due to CV events. Both baseline MR-proANP and MR-proADM were associated with higher risk of all-cause (HR = 1.44, p = 0.001 and HR = 1.32, p = 0.002, respectively) and CV mortality (HR = 1.75, p

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0017803

DOI: 10.1371/journal.pone.0017803

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