Cumulative Viral Load and Virologic Decay Patterns after Antiretroviral Therapy in HIV-Infected Subjects Influence CD4 Recovery and AIDS

Vincent C Marconi, Greg Grandits, Jason F Okulicz, Glenn Wortmann, Anuradha Ganesan, Nancy Crum-Cianflone, Michael Polis, Michael Landrum, Matthew J Dolan, Sunil K Ahuja, Brian Agan, Hemant Kulkarni and the Infectious Disease Clinical Research Program (IDCRP) HIV Working Group

PLOS ONE, 2011, vol. 6, issue 5, 1-9

Abstract: Background: The impact of viral load (VL) decay and cumulative VL on CD4 recovery and AIDS after highly-active antiretroviral therapy (HAART) is unknown. Methods and Findings: Three virologic kinetic parameters (first year and overall exponential VL decay constants, and first year VL slope) and cumulative VL during HAART were estimated for 2,278 patients who initiated HAART in the U.S. Military HIV Natural History Study. CD4 and VL trajectories were computed using linear and nonlinear Generalized Estimating Equations models. Multivariate Poisson and linear regression models were used to determine associations of VL parameters with CD4 recovery, adjusted for factors known to correlate with immune recovery. Cumulative VL higher than the sample median was independently associated with an increased risk of AIDS (relative risk 2.38, 95% confidence interval 1.56–3.62, p

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0017956

DOI: 10.1371/journal.pone.0017956

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