Hsa-miR-196a2 Rs11614913 Polymorphism Contributes to Cancer Susceptibility: Evidence from 15 Case-Control Studies

Haiyan Chu, Meilin Wang, Danni Shi, Lan Ma, Zhizhong Zhang, Na Tong, Xinying Huo, Wei Wang, Dewei Luo, Yan Gao and Zhengdong Zhang

PLOS ONE, 2011, vol. 6, issue 3, 1-6

Abstract: Background: MicroRNAs (miRNAs) are a family of endogenous, small and noncoding RNAs that negatively regulate gene expression by suppressing translation or degrading mRNAs. Recently, many studies investigated the association between hsa-miR-196a2 rs11614913 polymorphism and cancer risk, which showed inconclusive results. Methodology/Principal Findings: We conducted a meta-analysis of 15 studies that included 9,341 cancer cases and 10,569 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, individuals with the TC/CC genotypes were associated with higher cancer risk than those with the TT genotype (OR = 1.18, 95% CI = 1.03–1.34, P

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0018108

DOI: 10.1371/journal.pone.0018108

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