IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection

Chun-Yen Lin, Ji-Yih Chen, Tsung-Nan Lin, Wen-Juei Jeng, Chien-Hao Huang, Chang-Wen Huang, Su-Wei Chang and I-Shyan Sheen

PLOS ONE, 2011, vol. 6, issue 3, 1-9

Abstract: Background: Single nucleotide polymorphisms (SNPs) of interleukin-28B (IL28B) have received considerable interest for their association with sustained virological response (SVR) when treating patients of genotype-1 hepatitis C virus (GT1-HCV) chronic infection with pegylated interferon and ribavirin (PegIFN/RBV). This study was to investigate the predictive power of IL28B SNPs for on-treatment responses and SVR in treatment-naïve patients with GT1-HCV chronic infection. Methodology/Principal Findings: We analyzed ten SNPs of IL28B in 191 treatment-naïve patients with GT1-HCV chronic infection who received PegIFN/RBV. In these patients, rapid virological response (RVR), early virological response (EVR) and SVR were achieved in 69.6%, 95.8% and 68.6% of the patients, respectively. Multivariate analysis (odds ratio; 95% confidence interval; P value) indicated age (0.96; 0.93–0.99; 0.012), low baseline viral load (4.65; 2.23–9.66;

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0018322

DOI: 10.1371/journal.pone.0018322

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