Improving the Characterization of Radiologically Isolated Syndrome Suggestive of Multiple Sclerosis

Nicola De Stefano, Maria Laura Stromillo, Francesca Rossi, Marco Battaglini, Antonio Giorgio, Emilio Portaccio, Bahia Hakiki, Gianmichele Malentacchi, Claudio Gasperini, Mario Santangelo, Maria Letizia Bartolozzi, Maria Pia Sormani, Antonio Federico and Maria Pia Amato

PLOS ONE, 2011, vol. 6, issue 4, 1-9

Abstract: Objective: To improve the characterization of asymptomatic subjects with brain magnetic resonance imaging (MRI) abnormalities highly suggestive of multiple sclerosis (MS), a condition named as “radiologically isolated syndrome” (RIS). Methods: Quantitative MRI metrics such as brain volumes and magnetization transfer (MT) were assessed in 19 subjects previously classified as RIS, 20 demographically-matched relapsing-remitting MS (RRMS) patients and 20 healthy controls (HC). Specific measures were: white matter (WM) lesion volumes (LV), total and regional brain volumes, and MT ratio (MTr) in lesions, normal-appearing WM (NAWM) and cortex. Results: LV was similar in RIS and RRMS, without differences in distribution and frequency at lesion mapping. Brain volumes were similarly lower in RRMS and RIS than in HC (p

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0019452

DOI: 10.1371/journal.pone.0019452

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