Incorporation of Extranodal Metastasis of Gastric Carcinoma into the 7th Edition UICC TNM Staging System

Wei Wang, Yuanfang Li, Yu Zhang, Xiuhong Yuan, Dazhi Xu, Yuanxiang Guan, Xingyu Feng, Yingbo Chen, Xiaowei Sun, Wei Li, Youqing Zhan and Zhiwei Zhou

PLOS ONE, 2011, vol. 6, issue 6, 1-8

Abstract: Background: To assess the clinical significance and prognostic impact of extranodal metastasis (EM) in gastric carcinoma and establish an optimal classification in the staging system. Methodology/Principal Findings: A total of 1343 patients with gastric carcinoma who underwent surgical resection were recruited to determine the frequency and prognostic significance of EMs. EMs were divided into two groups (EM1 and EM2) and then incorporated into the 7th edition UICC TNM staging system. EMs was detected in 179 (13.3%) of 1343 patients who underwent radical resection. Multivariate analysis identified EMs as an independent prognostic factor (HR = 1.412, 95%CI = 1.151–1.731, P

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0019557

DOI: 10.1371/journal.pone.0019557

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