Incidence and Risk Factors of Serious Adverse Events during Antituberculous Treatment in Rwanda: A Prospective Cohort Study

Natalie Lorent, Osee Sebatunzi, Gloria Mukeshimana, Jef Van den Ende and Joannes Clerinx

PLOS ONE, 2011, vol. 6, issue 5, 1-8

Abstract: Background: Tuberculosis (TB) and TB-human immunodeficiency virus infection (HIV) coinfection is a major public health concern in resource-limited settings. Although TB treatment is challenging in HIV-infected patients because of treatment interactions, immunopathological reactions, and concurrent infections, few prospective studies have addressed this in sub-Saharan Africa. Methods and findings: Prospective observational cohort study of adults treated for TB at the Internal Medicine department of the Kigali University Hospital from May 2008 through August 2009. Conclusion: Adverse events frequently complicate the course of antituberculous treatment and worsen treatment outcome, particularly in patients with extrapulmonary TB and advanced immunodeficiency. Concurrent infection accounts for most events. Our data suggest that deterioration in a patient already receiving antituberculous treatment should prompt an aggressive search for additional infections.

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0019566

DOI: 10.1371/journal.pone.0019566

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